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Found 57 with Last Name = 'bartulis' and Initial = 's'
LigandPNGBDBM50380371(CHEMBL2017970)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380366(CHEMBL2017965)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380369(CHEMBL2017968)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380367(CHEMBL2017966)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336877(5,5'-(2-morpholinopyrimidine-4,6-diyl)dipyrimidin-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336875(CHEMBL1672324 | N2'-methyl-2-morpholino-N6-(quinol...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380370(CHEMBL2017969)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380372(CHEMBL2016592)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336873(CHEMBL1672321 | N-(2-morpholino-4,5'-bipyrimidin-6...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PI3Kgamma after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336878(2-morpholino-N6-(tetrahydro-2H-pyran-4-yl)-4,5'-bi...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380377(CHEMBL2017977 | WO2007/084786, Compound 85)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
LigandPNGBDBM50380376(CHEMBL2017976)
Affinity DataIC50:  15nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380365(CHEMBL2017971)
Affinity DataIC50:  18.4nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kdelta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380368(CHEMBL2017967)
Affinity DataIC50:  21nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380375(CHEMBL2017975)
Affinity DataIC50:  23nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  30nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380373(CHEMBL2017972)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336872(CHEMBL1672320 | N-(6-(5-aminopyrazin-2-yl)-2-morph...)
Affinity DataIC50:  44nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  52nMAssay Description:Inhibition of PI3K p110alpha subunit using [gamma33P]ATP by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336868(CHEMBL1672316 | N-(6-(6-aminopyridin-3-yl)-2-morph...)
Affinity DataIC50:  55nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336866(3-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-...)
Affinity DataIC50:  61nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336869(CHEMBL1672317 | N-(6-(3H-imidazo[4,5-b]pyridin-6-y...)
Affinity DataIC50:  66nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380374(CHEMBL2017973)
Affinity DataIC50:  68nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50:  92nMAssay Description:Inhibition of PI3Kbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336868(CHEMBL1672316 | N-(6-(6-aminopyridin-3-yl)-2-morph...)
Affinity DataIC50:  110nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  116nMAssay Description:Inhibition of PI3K p110delta subunit using [gamma33P]ATP by filter binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM50336867(CHEMBL1672315 | N-(2-morpholino-6-(pyridin-3-yl)py...)
Affinity DataIC50:  135nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380364(CHEMBL2017978)
Affinity DataIC50:  142nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  166nMAssay Description:Inhibition of PI3K p110beta subunit using [gamma33P]ATP by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336871(CHEMBL1672319 | N-(2-morpholino-6-(pyrazin-2-yl)py...)
Affinity DataIC50:  231nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336876(CHEMBL1672325 | N2',N2'-dimethyl-2-morpholino-N6-(...)
Affinity DataIC50:  247nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336870(4-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-...)
Affinity DataIC50:  253nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  262nMAssay Description:Inhibition of PI3K p110gamma subunit using [gamma33P]ATP by filter binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM50336874(2-morpholino-6-(quinolin-3-ylamino)-4,5'-bipyrimid...)
Affinity DataIC50:  774nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of PI3K VPS34 using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of mTOR after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of mTOR after 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of PI4Kbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of VPS34 after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of PI4Kbeta using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336881(2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyr...)
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336880(2-morpholino-N6-(quinolin-3-yl)-4,5'-bipyrimidine-...)
Affinity DataEC50:  40nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336871(CHEMBL1672319 | N-(2-morpholino-6-(pyrazin-2-yl)py...)
Affinity DataEC50:  390nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336866(3-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-...)
Affinity DataEC50:  370nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336867(CHEMBL1672315 | N-(2-morpholino-6-(pyridin-3-yl)py...)
Affinity DataEC50:  650nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336868(CHEMBL1672316 | N-(6-(6-aminopyridin-3-yl)-2-morph...)
Affinity DataEC50:  310nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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