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Found 195 with Last Name = 'baumann' and Initial = 'c'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318372((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11123((2S)-1-[(2S)-2-amino-3-[4-(2,4-difluorophenyl)phen...)
Affinity DataKi:  2.20nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11121((2S)-1-[(2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]p...)
Affinity DataKi:  3.10nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318382(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318375((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-3-fl...)
Affinity DataKi:  4.01nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11122((2S)-1-[(2S)-2-amino-3-[4-(2-fluorophenyl)phenyl]p...)
Affinity DataKi:  5.30nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318381((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-f...)
Affinity DataKi:  5.42nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50323923((E)-3-((2-(Fluoromethyl)thiazol-4-yl)ethynyl)cyclo...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318380((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(2-f...)
Affinity DataKi:  8.41nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318374((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Affinity DataKi:  9.15nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11118((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...)
Affinity DataKi:  13nM ΔG°:  -45.0kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11119((2S)-1-[(2S)-2-amino-3-[4-(4-methylphenyl)phenyl]p...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50323924((E)-3-(Thiazol-2-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  20.3nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50323926((E)-3-((2-Methylthiazol-4-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  21.9nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11120((2S)-1-[(2S)-2-amino-3-[4-(3,4-dimethoxyphenyl)phe...)
Affinity DataKi:  26nM ΔG°:  -43.3kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318383((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  26.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11113(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Affinity DataKi:  27nM ΔG°:  -43.2kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11116((2S)-1-[(2S)-2-amino-3-(4-iodophenyl)propanoyl]pyr...)
Affinity DataKi:  34nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50323925((E)-3-(Thiazol-4-ylethynyl)cyclohex-2-enone O-2-(2...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11124((2S)-1-[(2S)-2-amino-3-[4-(furan-2-yl)phenyl]propa...)
Affinity DataKi:  36nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318376((Z)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Affinity DataKi:  44.0nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318373((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  46.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318377((Z)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  49.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318371((E)-3-(pyridin-4-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  54.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318379((E)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  56.1nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11115((2S)-1-[(2S)-2-amino-3-phenylpropanoyl]pyrrolidine...)
Affinity DataKi:  63nM ΔG°:  -41.1kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318378((E)-2-fluoro-4-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  73.4nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11136((2S)-2-amino-3-[4-(2,4-difluorophenyl)phenyl]-1-(1...)
Affinity DataKi:  96nM ΔG°:  -40.1kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM39687((2E)-1-ethyl-2-[(1-ethyl-2-quinolin-1-iumyl)methyl...)
Affinity DataKi:  100nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11134(4-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  160nM ΔG°:  -38.8kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11133(3-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  166nM ΔG°:  -38.7kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11135((2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]-1-(1,3-t...)
Affinity DataKi:  170nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM50420192(CHEMBL2074851)
Affinity DataKi:  210nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318370((E)-3-(pyridin-3-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  252nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11132(4-{4-[(2S)-2-amino-3-oxo-3-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  310nM ΔG°:  -37.1kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11131((2S)-2-amino-3-[4-(pyridin-2-yl)phenyl]-1-(1,3-thi...)
Affinity DataKi:  355nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11125((2S)-2-amino-3-(4-phenylphenyl)-1-(1,3-thiazolidin...)
Affinity DataKi:  360nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11117(4-[(2S)-2-amino-3-[(2S)-2-cyanopyrrolidin-1-yl]-3-...)
Affinity DataKi:  470nM ΔG°:  -36.1kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11130((2S)-2-amino-3-(4-iodophenyl)-1-(1,3-thiazolidin-3...)
Affinity DataKi:  980nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11126((2S)-2-amino-3-(4-phenylphenyl)-1-(pyrrolidin-1-yl...)
Affinity DataKi:  1.16E+3nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM50420181(CHEMBL2074704)
Affinity DataKi:  1.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM81945(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)
Affinity DataKi:  2.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataKi:  3.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T

Curated by ChEMBL
LigandPNGBDBM50420216(MEPIPERPHENIDOL BROMIDE)
Affinity DataKi:  4.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11137((2S)-2-amino-3-(naphthalen-2-yl)-1-(1,3-thiazolidi...)
Affinity DataKi:  8.90E+3nM ΔG°:  -28.8kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11127((2S)-2-amino-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1...)
Affinity DataKi: >1.28E+4nM ΔG°: >-27.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11128((2S)-2-amino-1-[(2S)-2-[(benzyloxy)methyl]pyrrolid...)
Affinity DataKi: >1.28E+4nM ΔG°: >-27.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11129((2S)-2-amino-1-(2,2-dimethyl-1,3-oxazolidin-3-yl)-...)
Affinity DataKi: >1.28E+4nM ΔG°: >-27.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11139((2S)-2-amino-3-(1H-indol-3-yl)-1-(1,3-thiazolidin-...)
Affinity DataKi: >1.28E+4nM ΔG°: >-27.9kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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