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Found 1603 with Last Name = 'beck' and Initial = 'e'
TargetNeuraminidase(Influenza B virus (B/Lee/40))
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM4707(3-(2,2-diaminoimino)-4-methylcarboxamidobenzoate |...)
Affinity DataKi:  2.5nMAssay Description:In vitro inhibitory activity of the compound against B/Lee/40 Influenza B Neuraminidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128678(CHEMBL310855 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2...)
Affinity DataKi:  8.40nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128679(CHEMBL77784 | N-(1-Carbamoyl-pentyl)-2-[2-(4-dimet...)
Affinity DataKi:  13.3nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128680(CHEMBL80903 | N-(1-Benzyl-2-oxo-ethyl)-2-(2-naphth...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  15.5nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  18nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128681(CHEMBL80933 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-...)
Affinity DataKi:  18.3nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128679(CHEMBL77784 | N-(1-Carbamoyl-pentyl)-2-[2-(4-dimet...)
Affinity DataKi:  27nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128682(CHEMBL80605 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128682(CHEMBL80605 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-...)
Affinity DataKi:  62nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128681(CHEMBL80933 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-...)
Affinity DataKi:  83nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50128678(CHEMBL310855 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2...)
Affinity DataKi:  99nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50112839(CHEMBL26631 | N-(1-Benzyl-2-oxo-ethyl)-2-styryl-be...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50078263(1-(5-Bromo-pyridin-2-yl)-3-[2-(2-fluoro-phenyl)-et...)
Affinity DataKi:  600nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant HIV-1 Reverse transcriptase using cell free RT inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1866(3-(5-bromopyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]t...)
Affinity DataKi:  600nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50112838(CHEMBL281874 | N-(1-Benzyl-2-oxo-ethyl)-benzamide)
Affinity DataKi:  1.08E+3nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091963(1-(5-Bromo-pyridin-2-yl)-3-((R)-1-cyclohexyl-ethyl...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091962(1-(5-Chloro-pyridin-2-yl)-3-((R)-1-cyclohexyl-ethy...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091966(1-((R)-1-Cyclohexyl-ethyl)-3-thiazol-2-yl-thiourea...)
Affinity DataKi:  1.20E+4nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant HIV-1 Reverse transcriptase using cell free RT inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091972(1-(5-Bromo-pyridin-2-yl)-3-((S)-1-cyclohexyl-ethyl...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091970(1-((S)-1-Cyclohexyl-ethyl)-3-thiazol-2-yl-thiourea...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091973(1-(5-Chloro-pyridin-2-yl)-3-((S)-1-cyclohexyl-ethy...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091964(1-((S)-1-Cyclohexyl-ethyl)-3-pyridin-2-yl-thiourea...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50091971(1-((R)-1-Cyclohexyl-ethyl)-3-pyridin-2-yl-thiourea...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against HIV reverse transcriptase (Estimated Ki)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM160666(US9045498, 8)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615089(CHEMBL5270693)
Affinity DataIC50:  0.00800nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM223332(US9315520, 19 | US9605007, Example 19 | US9744173,...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615089(CHEMBL5270693)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259962(CHEMBL4088234)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of BACE1 in human H4 cells expressing wild type APP695 assessed as reduction in soluble APPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50:  0.0250nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  0.0290nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50452875(CHEMBL4212046)
Affinity DataIC50:  0.0330nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50452884(CHEMBL4217023)
Affinity DataIC50:  0.0340nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615093(CHEMBL5284924)
Affinity DataIC50:  0.0530nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  0.0590nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615093(CHEMBL5284924)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50452883(CHEMBL4203860)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615094(CHEMBL5285052)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250852(CHEMBL4078217)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615092(CHEMBL5289859)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615097(CHEMBL5275642)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 1...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250859(CHEMBL4097203)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250848(CHEMBL4059676)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104526(3-[2-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615094(CHEMBL5285052)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 m...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250855(CHEMBL4077745)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50615092(CHEMBL5289859)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
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