Found 253 with Last Name = 'becker' and Initial = 'sl' 
Affinity DataKi: 293nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
Affinity DataIC50: 0.178nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 0.225nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.75nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
