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Found 173 with Last Name = 'bedford' and Initial = 'mt'
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50560742(CHEMBL4761603)
Affinity DataIC50:  12nMAssay Description:Inhibition of human PRMT5/MEP50 assessed as reduction in methyltransferase activity using histone 4 peptide as substrate in presence of [3H]SAM incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50560741(CHEMBL4749319)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PRMT5/MEP50 assessed as reduction in methyltransferase activity using histone 4 peptide as substrate in presence of [3H]SAM incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM177922(US10307413, Compound 337 | US10391089, Compound 16...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PRMT5/MEP50 assessed as reduction in methyltransferase activity using histone 4 peptide as substrate in presence of [3H]SAM incub...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598000(CHEMBL5209447)
Affinity DataIC50:  43nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  68nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  113nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  176nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598017(CHEMBL5206272)
Affinity DataIC50:  220nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  226nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50:  320nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598011(CHEMBL5203516)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  410nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598017(CHEMBL5206272)
Affinity DataIC50:  420nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  550nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  631nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  778nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  835nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  860nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598010(CHEMBL5179077)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346713(CHEMBL1797447)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598008(CHEMBL5199851)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  1.68E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598001(CHEMBL5196058)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598003(CHEMBL5204851)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  3.82E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  4.05E+3nMAssay Description:Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  4.34E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  4.86E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50346718(CHEMBL1797553)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  5.84E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598017(CHEMBL5206272)
Affinity DataIC50:  5.87E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50347705(CHEMBL1802461)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CARM1-mediated methylation of PABP1 after 90 mins by scintillation counting in presence of S-adenosyl-l-[methyl-3H]methionineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50:  8.29E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598017(CHEMBL5206272)
Affinity DataIC50:  8.46E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50347703(CHEMBL261261)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of CARM1-mediated methylation of PABP1 after 90 mins by scintillation counting in presence of S-adenosyl-l-[methyl-3H]methionineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598014(CHEMBL2179350)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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