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Found 115 with Last Name = 'benbow' and Initial = 'j'
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of DPP4 in rat plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi:  14nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338507((3R,4S)-1-(6-(6,7-dihydroisoxazolo[4,3-c]pyridin-5...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277775((3R,4R)-3-(4-(3,5-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277776((3R,4R)-3-(4-(3,4-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278106((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277814((3R,4R)-2-(cyclopropylmethyl)-1-oxo-3-(4-phenoxyph...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338517(1-((3S,4S)-4-amino-1-(6-(3,3-difluoropyrrolidin-1-...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277887((3R,4R)-3-(benzo[d]thiazol-2-yl)-2-(2-ethylbutyl)-...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277853((3R,4R)-3-(3,4-dichlorophenyl)-2-(2-ethylbutyl)-1-...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277728((3R,4R)-3-(4-((cis)-4-methylcyclohexyloxy)phenyl)-...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277729((3R,4R)-2-ethyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338509(1-((3S,4S)-4-amino-1-(6-(6,7-dihydroisoxazolo[4,3-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277852((3R,4R)-3-(3,4-dichlorophenyl)-2-((S)-2-methylbuty...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338504((3R,4S)-4-phenyl-1-(6-(2,3,5-trifluorophenyl)pyrim...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338519(1-((3S,4S)-4-amino-1-(6-(3,3-difluoropyrrolidin-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278103((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338510(6-((3R,4S)-3-amino-4-phenylpyrrolidin-1-yl)-N-cycl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278843((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277888((3R,4R)-3-(benzofuran-2-yl)-2-((S)-2-methylbutyl)-...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278104((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338515(1-((3S,4S)-4-amino-1-(6-(3,3-difluoropyrrolidin-1-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278842((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278105((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277777((3R,4R)-1-oxo-2-propyl-3-(4-(5-(trifluoromethyl)py...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278841((R)-(4-(1-amino-2-(2,4,5-trifluorophenyl)ethyl)pip...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338516(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338513(1-((3S,4S)-4-amino-1-(6-(6-methoxypyridin-3-yl)pyr...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338506(1-((3S,4S)-4-amino-1-(6-(2,4,5-trifluorophenyl)pyr...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338514(1-((3S,4S)-4-amino-1-(4-phenyl-1,3,5-triazin-2-yl)...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338512(1-((3S,4S)-4-amino-1-(6-(cyclopropylamino)pyrimidi...)
Affinity DataIC50:  74nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277849((3R,4R)-3-(3,4-dichlorophenyl)-1-oxo-2-propyl-1,2,...)
Affinity DataIC50:  89nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277774((3R,4R)-3-(4-(benzyloxy)phenyl)-1-oxo-2-propyl-1,2...)
Affinity DataIC50:  96nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277851((3R,4R)-3-(benzofuran-2-yl)-1-oxo-2-propyl-1,2,3,4...)
Affinity DataIC50:  119nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338508((3'S,4'S)-4'-amino-1'-(6-(6,7-dihydroisoxazolo[4,3...)
Affinity DataIC50:  153nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277813((3R,4R)-2-methyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4...)
Affinity DataIC50:  156nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277850((3R,4R)-3-(3-chlorophenyl)-1-oxo-2-propyl-1,2,3,4-...)
Affinity DataIC50:  228nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278840((R)-tert-butyl 4-(1-amino-2-(2,4,5-trifluorophenyl...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278839((R)-1-(piperidin-4-yl)-2-(2,4,5-trifluorophenyl)et...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338505((3'S,4'S)-4'-amino-1'-(6-(2,4,5-trifluorophenyl)py...)
Affinity DataIC50:  488nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338511((3'S,4'S)-4'-amino-1'-(6-(cyclopropylamino)pyrimid...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278777((R)-methyl 4-(1-amino-2-(2,4,5-trifluorophenyl)eth...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278698((R)-3-methyl-1-(2,4,5-trifluorophenyl)butan-2-amin...)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278838((R)-1-(pyridin-4-yl)-2-(2,4,5-trifluorophenyl)etha...)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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