Affinity DataIC50: 0.0300nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene
Curated by ChEMBL
Methylgene
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Neuroscience Research Centre
Curated by ChEMBL
Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene
Curated by ChEMBL
Methylgene
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene
Curated by ChEMBL
Methylgene
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair