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Found 106 with Last Name = 'beswick' and Initial = 'm'
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182718(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-5-methy...)
Affinity DataIC50:  148nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
Vernalis (R&D)

LigandPNGBDBM15361((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...)
Affinity DataIC50: <200nMpH: 7.4 T: 2°CAssay Description:The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: <200nMAssay Description:Inhibition of ATP-ase activity in human colon tumor cell line (HCT116)More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15393(3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-acetylphenyl...)
Affinity DataIC50:  258nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15399(3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-sulfamoylph...)
Affinity DataIC50:  461nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182707(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM20882(4-[4-(4-benzylpiperazin-1-yl)-1H-pyrazol-3-yl]-6-c...)
Affinity DataIC50:  600nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182712(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  740nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182712(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182715(4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZE...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182700(4-phenethyl-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM20882(4-[4-(4-benzylpiperazin-1-yl)-1H-pyrazol-3-yl]-6-c...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182707(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182702(4-chloro-6-(5-methyl-4-(piperazin-1-yl)-1H-pyrazol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447696(CHEMBL3112968)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
Vernalis (R&D)

LigandPNGBDBM15384(8-(2,5-dimethoxybenzyl)-2-fluoro-9-pent-4-ynyl-9H-...)
Affinity DataIC50:  4.10E+3nMpH: 7.4 T: 2°CAssay Description:The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM15384(8-(2,5-dimethoxybenzyl)-2-fluoro-9-pent-4-ynyl-9H-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ATP-ase activity in human colon tumour cell line (HCT116)More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182705(4-chloro-6-(4-(4-ethylpiperazin-1-yl)-1H-pyrazol-3...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182710(4-chloro-6-(4-(4-phenethylpiperazin-1-yl)-1H-pyraz...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447694(CHEMBL3112967)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182709(4-(4-(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)-...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15397(3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-fluoropheny...)
Affinity DataIC50:  5.35E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15398(3-(5-chloro-2,4-dihydroxyphenyl)-N-{[3-(trifluorom...)
Affinity DataIC50:  5.40E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182703(4-bromo-6-(4-(4-(ethylamino)piperidin-1-yl)-1H-pyr...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15395(3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-methoxyphen...)
Affinity DataIC50:  6.00E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15389(3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-methoxypheny...)
Affinity DataIC50:  6.00E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182714(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(pipera...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182718(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-5-methy...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15390(3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-chlorophenyl...)
Affinity DataIC50:  6.90E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15386(3-(5-chloro-2,4-dihydroxyphenyl)-N-phenyl-1H-pyraz...)
Affinity DataIC50:  7.10E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447696(CHEMBL3112968)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182715(4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZE...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182716(5-(4-Piperazin-1-yl-1H-pyrazol-3-yl)-biphenyl-2,4-...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182717(4-chloro-6-(4-(4-methylpiperazin-1-yl)-1H-pyrazol-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447695(CHEMBL3112966)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human recombinant DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182714(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(pipera...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182716(5-(4-Piperazin-1-yl-1H-pyrazol-3-yl)-biphenyl-2,4-...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182700(4-phenethyl-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182711(4-bromo-6-(4-(piperazin-1-yl)-1H-pyrazol-3-yl)benz...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447696(CHEMBL3112968)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447699(CHEMBL3112960)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15396(3-(5-chloro-2,4-dihydroxyphenyl)-N-[(3-methoxyphen...)
Affinity DataIC50:  1.07E+4nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447695(CHEMBL3112966)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182705(4-chloro-6-(4-(4-ethylpiperazin-1-yl)-1H-pyrazol-3...)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of HSP90 ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15388(3-(5-chloro-2,4-dihydroxyphenyl)-N-(3-methoxypheny...)
Affinity DataIC50:  1.17E+4nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15394(3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carbox...)
Affinity DataIC50:  1.28E+4nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50447694(CHEMBL3112967)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
Vernalis (R&D)

LigandPNGBDBM15359((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Affinity DataIC50:  1.34E+4nMpH: 7.4 T: 2°CAssay Description:The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM15359((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of ATP-ase activity in human colon tumour cell line (HCT116)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Vernalis

Curated by ChEMBL
LigandPNGBDBM50182713(4-(4-(4-(4-(methylsulfonyl)benzylamino)piperidin-1...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of HSP90 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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