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Found 194 with Last Name = 'bianchini' and Initial = 'g'
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50278487(CHEMBL3585376)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of 125-I echistatin from Vitronectin receptor (alpha v beta3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50278488(CHEMBL4159241)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction in NADPH consumption using varying levels of trypanothione disulfide as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50278486(CHEMBL4160100)
Affinity DataKi:  5.60E+3nMAssay Description:Mixed-type inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction in NADPH consumption using varying levels of trypanothione d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction in NADPH consumption using varying levels of trypanothione disulfide as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50278489(CHEMBL4170316)
Affinity DataKi:  2.24E+4nMAssay Description:Non-competitive inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction in NADPH consumption using varying levels of trypanothi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506987(4-hydroxy-2-(2-hydroxyphenyl)-N- methoxy-N-methyl-...)
Affinity DataIC50:  6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  11nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  12nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615856(CHEMBL5290716)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  16nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  17nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  18nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506978(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Affinity DataIC50:  18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  21nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM507003(1-[4-hydroxy-2-(3-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Affinity DataIC50:  23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50615856(CHEMBL5290716)
Affinity DataIC50:  24nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  24nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50:  28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50615870(CHEMBL5267628)
Affinity DataIC50:  32nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  32nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50016156(CHEMBL65312)
Affinity DataIC50:  32nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  36nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as decrease in outward currents by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615844(CHEMBL5273282)
Affinity DataIC50:  39nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM507011(1-[2-(4-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  50nMAssay Description:Inhibition of human TRPM8 I746A mutant expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615854(CHEMBL5271247)
Affinity DataIC50:  60nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  60nMAssay Description:Inhibition of human TRPM8 I746A mutant expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ effluxMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615861(CHEMBL5282352)
Affinity DataIC50:  61nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506996(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]b...)
Affinity DataIC50:  64nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506987(4-hydroxy-2-(2-hydroxyphenyl)-N- methoxy-N-methyl-...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
National Research Council

Curated by ChEMBL
LigandPNGBDBM50535869(CHEMBL4576619)
Affinity DataIC50:  72nMAssay Description:Antagonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium accumulation pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  75nMAssay Description:Inhibition of wild type human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ ef...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  76nMAssay Description:Inhibition of wild type human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ effluxMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615843(CHEMBL5271941)
Affinity DataIC50:  80nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615876(CHEMBL5279560)
Affinity DataIC50:  81nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506997(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]-...)
Affinity DataIC50:  85nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506983(4-hydroxy-N-methoxy-N-methyl-2- (2-methylphenyl)-1...)
Affinity DataIC50:  86nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506995(1-[4-hydroxy-2-(1-methyl-1H- pyrazol-4-yl)-1,3-thi...)
Affinity DataIC50:  89nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506978(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM506998(1-[4-hydroxy-2-(1,2,4-oxadiazol-3- yl)-1,3-thiazol...)
Affinity DataIC50:  99nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506988(1-[2-(2-hydroxyphenyl)-4-hydroxy- 1,3-thiazol-5-yl...)
Affinity DataIC50:  112nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506993(1-[4-hydroxy-2-(1-methyl-1H- imidazol-5-yl)-1,3-th...)
Affinity DataIC50:  112nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506991(1-[4-hydroxy-2-(1H-pyrrol-2-yl)-1,3- thiazol-5-yl]...)
Affinity DataIC50:  123nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506999(1-[4-hydroxy-2-(1,2-oxazol-5-yl)-1,3- thiazol-5-yl...)
Affinity DataIC50:  123nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50615829(CHEMBL5285498)
Affinity DataIC50:  131nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
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