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Found 16 with Last Name = 'biggs' and Initial = 'j'
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  9nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by whole cell patch clamp a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429204(CHEMBL2338549)
Affinity DataIC50:  21nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  23nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429205(CHEMBL2338551)
Affinity DataIC50:  28nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  40nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429206(CHEMBL2338550)
Affinity DataIC50:  41nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx by whole cell patch clamp ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429203(LYNGBYASTATIN 4)
Affinity DataIC50:  49nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Cavia porcellus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  63nMpH: 5.3Assay Description:Antagonist activity at guinea pig TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429201(CHEMBL2338554)
Affinity DataIC50:  78nMAssay Description:Inhibition of human neutrophil elastase-induced antiproliferative activity expressed in BEAS2B cells assessed as cytoprotectivity after 24 hrs by MTT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  100nMpH: 5.3Assay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429208(CHEMBL2338553)
Affinity DataIC50:  121nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  136nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429201(CHEMBL2338554)
Affinity DataIC50:  144nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429207(CHEMBL2338552)
Affinity DataIC50:  195nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263425(6-(4-fluorophenyl)-2-methyl-N-(quinolin-7-yl)nicot...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed