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Found 16 Enz. Inhib. hit(s) with Target = 'Neutrophil elastase' and Ligand = 'BDBM50084637'
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataKi:  24nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataKi:  37nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataKi:  200nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataKi:  200nMAssay Description:Binding affinity against Elastase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of elastase in human neutrophil using MeOSuc-AAPV-AMC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methyl-coumarin as substrate measured every 30 secs for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  44nMAssay Description:Inhibitory concentration of the compound was tested in vitro against Human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  44nMAssay Description:Inhibitory concentration against elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured for every 30 sec for 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human neutrophil elastase measured for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  128nMAssay Description:Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  136nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Mus musculus)
Chang Gung University

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  145nMAssay Description:Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  704nMAssay Description:Inhibition of human neutrophil elastase incubated for 40 mins in presence of Boc-Gln-Ala-Arg-AMC by fluorescence microtiter plate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed