TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO cells by FLIPR-based calcium mobilization assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO cells by FLIPR-based calcium mobilization assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO cells by FLIPR-based calcium mobilization assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 940nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125]CXCL10 from human CXCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair