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Found 120 with Last Name = 'blain' and Initial = 'jf'
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataIC50:  270nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50609447(CHEMBL5284728)
Affinity DataIC50:  340nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609452(CHEMBL5270350)
Affinity DataIC50:  510nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609448(CHEMBL5278585)
Affinity DataIC50:  680nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609449(CHEMBL5290639)
Affinity DataIC50:  690nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571307(CHEMBL566204)
Affinity DataIC50:  733nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571305(CHEMBL4857445)
Affinity DataIC50:  1.48E+3nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609451(CHEMBL5267232)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609467(CHEMBL5288288)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609464(CHEMBL5273870)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609461(CHEMBL5268245)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609472(CHEMBL5287100)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609460(CHEMBL5288534)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609454(CHEMBL5280684)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609469(CHEMBL5285699)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609465(CHEMBL5287033)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609457(CHEMBL5271222)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609458(CHEMBL5267767)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609450(CHEMBL5269880)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609459(CHEMBL5279044)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609466(CHEMBL5288607)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609468(CHEMBL5281792)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609463(CHEMBL5275548)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609456(CHEMBL5289822)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609455(CHEMBL5281603)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609453(CHEMBL5272819)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571303(CHEMBL4875543)
Affinity DataIC50:  9.40E+3nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in notch cleavageMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571308(CHEMBL4855033)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571304(CHEMBL4859485)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609471(CHEMBL5284190)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50609470(CHEMBL5268324)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571306(CHEMBL4850216)
Affinity DataIC50:  1.70E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609462(CHEMBL5289562)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571302(CHEMBL4873492)
Affinity DataIC50:  3.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50534352(CHEMBL4445103)
Affinity DataEC50:  20nMAssay Description:Modulation of gamma-secretase in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloid beta 42 production incubated overnig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50534353(CHEMBL4578751)
Affinity DataEC50:  6nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50534354(CHEMBL4547437)
Affinity DataEC50:  39nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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