TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 510nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 680nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 690nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 733nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 9.40E+3nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in notch cleavageMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Arkuda Therapeutics
Curated by ChEMBL
Arkuda Therapeutics
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Modulation of gamma-secretase in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloid beta 42 production incubated overnig...More data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san...More data for this Ligand-Target Pair