Compile Data Set for Download or QSAR
maximum 50k data
Found 353 with Last Name = 'blench' and Initial = 't'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120132(US8697708, 18)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120141(US8697708, 224)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120140(US8697708, 223)
Affinity DataKi:  0.400nM ΔG°:  -53.1kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583347(CHEMBL5080055)
Affinity DataKi:  0.400nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583341(CHEMBL5092805)
Affinity DataKi:  0.470nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120128(US8697708, 2)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120143(US8697708, 236)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307292(2-(2-Carbamimidoyl-benzo[b]thiophen-4-yloxy)-2-phe...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307291(4-[2-(2-Carbamimidoyl-benzo[b]thiophen-4-yloxy)-2-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120142(US8697708, 227)
Affinity DataKi:  0.800nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179077((4R,9aR)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120133(US8697708, 22)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120131(US8697708, 16)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120129(US8697708, 9)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120139(US8697708, 213)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583348(CHEMBL5093381)
Affinity DataKi:  1.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120137(US8697708, 129)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179080((4R,9aR)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583331(CHEMBL5089907)
Affinity DataKi:  1.80nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169261((4R,10aS)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307314(CHEMBL597557 | [2-Isobutylamino-methyl)-phenyl]-ca...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583333(CHEMBL5082573)
Affinity DataKi:  2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583333(CHEMBL5082573)
Affinity DataKi:  2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583338(CHEMBL5088939)
Affinity DataKi:  2.10nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583346(CHEMBL5078234)
Affinity DataKi:  2.20nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179087((4R,9aR)-6-[1-((S)-ethoxy)-ethyl]-4-methyl-1,2,3,4...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583349(CHEMBL5083540)
Affinity DataKi:  2.40nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583325(CHEMBL5093245)
Affinity DataKi:  2.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583351(CHEMBL5075876)
Affinity DataKi:  2.60nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307290(1-{4-[2-(2-Carbamimidoyl-benzo[b]thiophen-4-yloxy)...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM487146(US10952995, Compound 1-3)
Affinity DataKi:  2.70nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179086((4R,9aR)-4,6-dimethyl-1,2,3,4,9,9a-hexahydro-2,4a,...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583350(CHEMBL5078580)
Affinity DataKi:  2.80nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307308((R)-(4-Methoxy-phenyl)-carbamic acid 2-(2-carbamim...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307313((2-Methylamino-methyl-phenyl)-carbamic acid 2-(2-c...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307267(CHEMBL597759 | [2-(Piperazin-1-ylmethyl)-phenyl]-c...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307331((2-Carbamimidoylbenzo[b]thiophen-6-yloxy)thiophen-...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307277(CHEMBL604954 | [5-(Isopropylamino-methyl)-1,3-dime...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583340(CHEMBL5073693)
Affinity DataKi:  3.30nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307310(CHEMBL597143 | [4-(2-Dimethylamino-ethoxy)-phenyl]...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307312((2-Aminomethyl-phenyl)-carbamic acid 2-(2-carbamim...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM120138(US8697708, 138)
Affinity DataKi:  4.10nM ΔG°:  -47.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307279((2-Aminomethyl-phenyl)-carbamic acid 2-(2-carbamim...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307307((4-Methoxy-phenyl)-carbamic acid 2-(2-carbamimidoy...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307303((2-Fluoro-phenyl)-carbamic acid 2-(2-carbamimidoyl...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Trigen

Curated by ChEMBL
LigandPNGBDBM50307273((5-Methaminomethyl-2-methyl-2H-pyrazol-3-yl)-carba...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 353 total ) | Next | Last >>
Jump to: