Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -53.1kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 0.470nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nM ΔG°: -51.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -50.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nM ΔG°: -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nM ΔG°: -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nM ΔG°: -49.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nM ΔG°: -49.7kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Inhibition of factor 10a by amidolytic assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 2.80nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: 3.30nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nM ΔG°: -47.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human recombinant factor 9a by amidolytic assayMore data for this Ligand-Target Pair