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Found 138 with Last Name = 'boer' and Initial = 'r'
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50386178(CHEMBL1800346 | ONO-1714)
Affinity DataKi:  1.86nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50386178(CHEMBL1800346 | ONO-1714)
Affinity DataKi:  18.6nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27493(2-[4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl]-1,...)
Affinity DataIC50:  4.40nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27494(2-[4-(pyridin-2-yl)phenyl]-1,3-diazatricyclo[6.3.1...)
Affinity DataIC50:  15.4nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataIC50:  19nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27493(2-[4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl]-1,...)
Affinity DataIC50:  20nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27498(10-amino-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13...)
Affinity DataIC50:  22nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27494(2-[4-(pyridin-2-yl)phenyl]-1,3-diazatricyclo[6.3.1...)
Affinity DataIC50:  28nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27498(10-amino-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13...)
Affinity DataIC50:  32nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37.1nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418856(CHEMBL1800534)
Affinity DataIC50:  38.9nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  44.7nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27496((4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]-1,2,...)
Affinity DataIC50:  45nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418855(CHEMBL1800533)
Affinity DataIC50:  55.0nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataIC50:  62nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418844(CHEMBL1800347)
Affinity DataIC50:  70.8nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418849(CHEMBL1738840)
Affinity DataIC50:  81.3nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27499(1,11b-dihydro-[2H]benzopyrano[4,3,2-de]isoquinolin...)
Affinity DataIC50:  83nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27500(5,6-dihydrophenanthridin-6-one | 5H-Phenanthridin-...)
Affinity DataIC50:  85nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418845(CHEMBL1800348)
Affinity DataIC50:  115nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418851(CHEMBL1800528)
Affinity DataIC50:  145nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27501(1,5-dihydroxyisoquinoline | CHEMBL338314 | ISQ | i...)
Affinity DataIC50:  151nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418847(CHEMBL1800523)
Affinity DataIC50:  155nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27499(1,11b-dihydro-[2H]benzopyrano[4,3,2-de]isoquinolin...)
Affinity DataIC50:  186nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418860(CHEMBL1800526)
Affinity DataIC50:  186nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27500(5,6-dihydrophenanthridin-6-one | 5H-Phenanthridin-...)
Affinity DataIC50:  331nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27502(3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoq...)
Affinity DataIC50:  372nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418850(CHEMBL1800527)
Affinity DataIC50:  380nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27495(6-chloro-2,3-dimethylimidazo[1,2-a]pyridin-8-ol | ...)
Affinity DataIC50:  398nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418847(CHEMBL1800523)
Affinity DataIC50:  447nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27501(1,5-dihydroxyisoquinoline | CHEMBL338314 | ISQ | i...)
Affinity DataIC50:  447nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418859(CHEMBL1800531)
Affinity DataIC50:  513nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418854(CHEMBL1800532)
Affinity DataIC50:  724nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  741nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418853(CHEMBL1800530)
Affinity DataIC50:  776nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418847(CHEMBL1800523)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27503(5-AIQ | 5-amino-1,2-dihydroisoquinolin-1-one | 5-a...)
Affinity DataIC50:  1.18E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418856(CHEMBL1800534)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27502(3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoq...)
Affinity DataIC50:  1.74E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27503(5-AIQ | 5-amino-1,2-dihydroisoquinolin-1-one | 5-a...)
Affinity DataIC50:  1.82E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418855(CHEMBL1800533)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27495(6-chloro-2,3-dimethylimidazo[1,2-a]pyridin-8-ol | ...)
Affinity DataIC50:  1.95E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418852(CHEMBL1800529)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418849(CHEMBL1738840)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50418845(CHEMBL1800348)
Affinity DataIC50:  3.39E+3nMAssay Description:Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University of Konstanz

LigandPNGBDBM27496((4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]-1,2,...)
Affinity DataIC50:  4.17E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  5.89E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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