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Found 270 with Last Name = 'brault' and Initial = 'l'
LigandPNGBDBM50406141(CHEMBL5286547)
Affinity DataKi:  1.80E+3nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406139(CHEMBL5281816)
Affinity DataKi:  3.60E+3nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406140(CHEMBL5284779)
Affinity DataKi:  4.00E+3nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406144(CHEMBL5283506)
Affinity DataKi:  1.10E+4nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406145(CHEMBL5287800)
Affinity DataKi:  1.70E+4nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406143(CHEMBL5287916)
Affinity DataKi:  1.90E+4nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406142(CHEMBL5280788)
Affinity DataKi:  3.70E+4nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  8nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  24nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  41nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81550(Furan thiazolidinediones, A47)
Affinity DataIC50:  49nM Kd:  40nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81550(Furan thiazolidinediones, A47)
Affinity DataIC50:  49nM Kd:  23nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  60nMAssay Description:Inhibition of PIM1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHomeodomain-interacting protein kinase 2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81551(Furan thiazolidinediones, A64)
Affinity DataIC50:  74nM Kd:  9.5nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  83nMAssay Description:Inhibition of CaMK2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  90nMAssay Description:Inhibition of PIM3 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM36486(9-Cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-...)
Affinity DataIC50:  145nM Kd:  26nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  220nMAssay Description:Inhibition of ROCK2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  240nMAssay Description:Inhibition of PIM2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  300nMAssay Description:Inhibition of PKN2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  310nMAssay Description:Inhibition of PKN1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  330nMAssay Description:Inhibition of CK1alpha using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Turning Point Therapeutics

Curated by ChEMBL
LigandPNGBDBM50602137(CHEMBL5196998)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at TRPM5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Turning Point Therapeutics

Curated by ChEMBL
LigandPNGBDBM50602136(CHEMBL5183139)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at TRPM5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PKCtheta using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of MK5 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of PKCalpha using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PI4Kbeta using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PI3Kgamma using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197854(3-(4-heptadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human GST-Cdc25B expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197854(3-(4-heptadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197852((Z )-3-(4-(heptadec-8-enyl)-2,5-dioxo-2,5-dihydrof...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197856(3-(4-pentadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of PI3Kdelta using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197854(3-(4-heptadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197848(3-(4-tridecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)prop...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197855(3-(4-tetradecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197852((Z )-3-(4-(heptadec-8-enyl)-2,5-dioxo-2,5-dihydrof...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human GST-Cdc25B expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of KDR using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197856(3-(4-pentadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of human GST-Cdc25B expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of RET using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197848(3-(4-tridecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)prop...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197856(3-(4-pentadecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)pr...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of PI3Kbeta using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197848(3-(4-tridecyl-2,5-dioxo-2,5-dihydrofuran-3-yl)prop...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human GST-Cdc25B expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50197852((Z )-3-(4-(heptadec-8-enyl)-2,5-dioxo-2,5-dihydrof...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of VPS34 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of PI3Kalpha using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of mTOR using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ludwig-Maximilians University Of Munich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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