TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 2.60nM ΔG°: -45.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 6.20nM ΔG°: -43.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 6.80nM ΔG°: -43.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 11.3nM ΔG°: -42.2kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 12.7nM ΔG°: -41.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 15.7nM ΔG°: -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 20.7nM ΔG°: -40.8kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 22.2nM ΔG°: -40.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 28.8nM ΔG°: -40.0kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 43.2nM ΔG°: -39.1kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 45.3nM ΔG°: -39.0kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18.8nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 24.5nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Antagonist activity at CCR5 receptor (unknown origin) by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Binding affinity at CCR5 receptor by radiolabelled RANTES binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor cotransfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair