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Found 167 with Last Name = 'brittelli' and Initial = 'dr'
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288632(Boropeptide | CHEMBL607008)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288621((S)-1-[3-(2-Trifluoromethyl-benzyl)-benzoyl]-pyrro...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288628((S)-1-(3-Benzo[1,3]dioxol-5-ylmethyl-benzoyl)-pyrr...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000020(CHEMBL2448361)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288631((S)-1-[3-(3-Trifluoromethyl-benzyl)-benzoyl]-pyrro...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288634((S)-1-(3-Benzyl-benzoyl)-pyrrolidine-2-carboxylic ...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288623((S)-1-[3-(2-Methoxy-phenylsulfanyl)-benzoyl]-pyrro...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288627((S)-1-[3-(4-Trifluoromethyl-benzyl)-benzoyl]-pyrro...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288629((S)-1-[3-(2-Bromo-benzyl)-benzoyl]-pyrrolidine-2-c...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288620(Boropeptide | CHEMBL3038261)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288637((S)-1-[3-(2-Methyl-benzyl)-benzoyl]-pyrrolidine-2-...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288630((S)-1-(2-Phenoxy-benzoyl)-pyrrolidine-2-carboxylic...)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288636((S)-1-(2-Benzyl-benzoyl)-pyrrolidine-2-carboxylic ...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288615((3S,4R)-3-{(S)-2-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9...)
Affinity DataKi:  0.320nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288626((S)-1-(3-Phenoxy-benzoyl)-pyrrolidine-2-carboxylic...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288633((S)-1-[3-(4-Methoxy-phenylsulfanyl)-benzoyl]-pyrro...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288625((S)-1-[3-(3-Fluoro-benzyl)-benzoyl]-pyrrolidine-2-...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288624((S)-1-[3-(2-Trifluoromethyl-phenylsulfanyl)-benzoy...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288619(Boropeptide | CHEMBL3037937)
Affinity DataKi:  0.460nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288616((S)-1-[(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrol...)
Affinity DataKi:  0.5nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288639((S)-1-[3-(2-Methylsulfanyl-benzyl)-benzoyl]-pyrrol...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288622((S)-1-[3-(2-Methoxy-benzenesulfonyl)-benzoyl]-pyrr...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288617(Boropeptide | CHEMBL2448349)
Affinity DataKi:  0.780nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288408(1-(3-Phenyl-propionyl)-pyrrolidine-2-carboxylic ac...)
Affinity DataKi:  0.800nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288408(1-(3-Phenyl-propionyl)-pyrrolidine-2-carboxylic ac...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288638((S)-1-(3-Benzenesulfonyl-benzoyl)-pyrrolidine-2-ca...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288635((S)-1-(4-Benzyl-benzoyl)-pyrrolidine-2-carboxylic ...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288614((3R,4S)-3-{(S)-2-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288618((S)-1-[(3R,4S)-4-(3-Trifluoromethyl-phenyl)-pyrrol...)
Affinity DataKi:  5.60nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288613((S)-1-((1S,2S)-2-Phenyl-cyclohexanecarbonyl)-pyrro...)
Affinity DataKi:  30nMAssay Description:Compound was evaluated for the inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139601(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312157(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312156(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312157(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Affinity DataIC50:  26nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139614(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139618(4-{4-[3-(4-Bromo-3-trifluoromethyl-phenyl)-ureido]...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Tie2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  35nMAssay Description:Inhibition of EPHA2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  37nMAssay Description:Inhibition of EphB4 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312156(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Tie2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312184(1-(2-hydroxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  37nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139621(4-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-pheno...)
Affinity DataIC50:  38nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139626(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312156(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Affinity DataIC50:  49nMAssay Description:Inhibition of EphB4 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Tie2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312157(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Affinity DataIC50:  50nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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