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Found 345 with Last Name = 'broom' and Initial = 'a'
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  7nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022736(2-[4-({2-Amino-5-[1-(4-hydroxy-5-phosphonooxymethy...)
Affinity DataKi:  27nMAssay Description:Inhibition of human thymidylate synthase at 600 uM concentration of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50227822(CHEMBL3392216)
Affinity DataKi:  30nMAssay Description:Inhibition of compound against thymidylate synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022737(2-{4-[(2-{(2-Amino-4-methyl-6-oxo-1,6-dihydro-pyri...)
Affinity DataKi:  37nMAssay Description:Inhibition of human thymidylate synthase at 600 uM concentration of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028107(2-{4-[(2-Amino-5-{1-[5-(dihydroxy-phosphanyloxymet...)
Affinity DataKi:  58nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017764(CHEMBL3392217 | Phosphoric acid mono-{3-hydroxy-5-...)
Affinity DataKi:  60nMAssay Description:Inhibition of compound against thymidylate synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022736(2-[4-({2-Amino-5-[1-(4-hydroxy-5-phosphonooxymethy...)
Affinity DataKi:  85nMAssay Description:Competitive inhibition of the human thymidylate synthase at 600 uM of [dUMP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022737(2-{4-[(2-{(2-Amino-4-methyl-6-oxo-1,6-dihydro-pyri...)
Affinity DataKi:  230nMAssay Description:Competitive inhibition of the human thymidylate synthase at 28 uM as Ki(slope) of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028107(2-{4-[(2-Amino-5-{1-[5-(dihydroxy-phosphanyloxymet...)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017762(2-(4-{[2-Amino-5-(2,4-dioxo-1,2,3,4-tetrahydro-pyr...)
Affinity DataKi:  750nMAssay Description:Inhibition of compound against thymidylate synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50023905(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against thymidylate synthase from murine leukemia L1210More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028108(2'-Deoxyuridinemonophosphate | DEOXYURIDINE MONOPH...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndolethylamine N-methyltransferase(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50367839(CHEMBL2368635)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of compound against indole N-methyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity against human enzyme thymidylate synthase derived from either HeLa or KB cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R](Rattus norvegicus (Rat))
University of Waterloo

LigandPNGBDBM223201(β-Sulfopyruvate)
Affinity DataKi:  3.70E+4nMAssay Description:The inhibition of H477R PEPCK by β-sulfopyruvate (βSP), oxalate, and GMPPCP was conducted in the direction of PEP synthesis (OAA → PE...More data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50227823(CHEMBL3392214)
Affinity DataKi:  9.30E+4nMAssay Description:Inhibition of compound against Guanine-7-methyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028109(2-{4-[(2-Amino-5-{1-[4-hydroxy-5-(hydroxy-methoxy-...)
Affinity DataKi:  1.20E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028110(2-[4-({2-Amino-5-[1-(4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataKi:  1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028106(CHEMBL46945 | diethyl 2-{4-[2-amino-4-oxo-3,4,5,6,...)
Affinity DataKi:  1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of N5, 10-CH2-H4PteGlu and fixed dUMP (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rattus norvegicus (Rat))
University of Waterloo

LigandPNGBDBM223202(β,γ-methyleneguanosine 5′-triphosp...)
Affinity DataKi:  1.50E+5nMAssay Description:The inhibition of H477R PEPCK by β-sulfopyruvate (βSP), oxalate, and GMPPCP was conducted in the direction of PEP synthesis (OAA → PE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028106(CHEMBL46945 | diethyl 2-{4-[2-amino-4-oxo-3,4,5,6,...)
Affinity DataKi:  1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of N5, 10-CH2-H4PteGlu and fixed dUMP (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028110(2-[4-({2-Amino-5-[1-(4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R](Rattus norvegicus (Rat))
University of Waterloo

LigandPNGBDBM50366413(PHOSPHOENOLPYRUVATE)
Affinity DataKi:  2.89E+5nMAssay Description:The inhibition of H477R PEPCK by β-sulfopyruvate (βSP), oxalate, and GMPPCP was conducted in the direction of PEP synthesis (OAA → PE...More data for this Ligand-Target Pair
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R](Rattus norvegicus (Rat))
University of Waterloo

LigandPNGBDBM23230(2-Oxosuccinic acid | 2-oxobutanedioic acid | Oxalo...)
Affinity DataKi:  4.41E+5nMAssay Description:The inhibition of H477R PEPCK by β-sulfopyruvate (βSP), oxalate, and GMPPCP was conducted in the direction of PEP synthesis (OAA → PE...More data for this Ligand-Target Pair
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R](Rattus norvegicus (Rat))
University of Waterloo

LigandPNGBDBM223202(β,γ-methyleneguanosine 5′-triphosp...)
Affinity DataKi:  6.96E+5nMAssay Description:The inhibition of H477R PEPCK by β-sulfopyruvate (βSP), oxalate, and GMPPCP was conducted in the direction of PEP synthesis (OAA → PE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028109(2-{4-[(2-Amino-5-{1-[4-hydroxy-5-(hydroxy-methoxy-...)
Affinity DataKi:  7.00E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384121(CHEMBL2029678)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384121(CHEMBL2029678)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384128(CHEMBL2029686)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078377(CHEMBL3414922)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384118(CHEMBL2029563)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50156350(CHEMBL3785199)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078374(CHEMBL3414926)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384121(CHEMBL2029678)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384120(CHEMBL2029565)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50156350(CHEMBL3785199)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50157612(CHEMBL3785909)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50157535(CHEMBL3787004)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384120(CHEMBL2029565)
Affinity DataIC50:  2nMAssay Description:Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384121(CHEMBL2029678)
Affinity DataIC50:  2nMAssay Description:Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cellsMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384114(CHEMBL2029680)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50384129(CHEMBL2029687)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078375(CHEMBL3414925)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078376(CHEMBL3414923)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078381(CHEMBL3414918)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50078385(CHEMBL3414914)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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