Compile Data Set for Download or QSAR
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Found 27 with Last Name = 'broussy' and Initial = 's'
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  690nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555880(CHEMBL4781198)
Affinity DataIC50:  930nMAssay Description:Inhibition of recombinant human SIRT2 expressed in baculovirus infected SF9 cells expression system using RHKK(Ac)W-NH2 as substrate measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant human SIRT2 expressed in baculovirus infected SF9 cells expression system using RHKK(Ac)W-NH2 as substrate measured after 2...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555881(CHEMBL4781200)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555883(CHEMBL4740942)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555880(CHEMBL4781198)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555875(CHEMBL4740949)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555879(CHEMBL4784071)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555878(CHEMBL4746325)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555877(CHEMBL4800250)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555882(CHEMBL4750361)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50190131(Oblongifolin C)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human recombinant GST-fused SIRT1 expressed in Escherichia coli DH5-alpha using [3H]acetic acid labeled MPSDKTIGG as substrate after ov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257256(CHEMBL4092853)
Affinity DataIC50:  1.04E+4nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555876(CHEMBL4744001)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50190131(Oblongifolin C)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of human recombinant GST-fused SIRT2 expressed in Escherichia coli DH5-alpha using [3H]acetic acid labeled MPSDKTIGG as substrate after ov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50195222(CHEMBL3894424)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human SIRT1 preincubated with enzyme followed by Fluor de Lys substrate addition by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257258(CHEMBL4062433)
Affinity DataIC50:  5.04E+4nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257253(CHEMBL4077087)
Affinity DataIC50:  5.60E+4nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257257(CHEMBL4071072)
Affinity DataIC50:  7.51E+4nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555873(CHEMBL4751492)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50555874(CHEMBL4784313)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257259(CHEMBL4083044)
Affinity DataIC50:  1.30E+5nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50195222(CHEMBL3894424)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of human SIRT2 preincubated with enzyme followed by Fluor de Lys substrate addition by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257261(CHEMBL4090414)
Affinity DataIC50:  1.57E+5nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50521337(CHEMBL4592007)
Affinity DataIC50:  1.96E+5nMAssay Description:Displacement of biotinylated VEGF-A165 from human VEGFR-1 ECD incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50257260(CHEMBL4090834)
Affinity DataIC50:  2.71E+5nMAssay Description:Displacement of biotinylated VEGF-A (165 residues) from humanized recombinant C-terminal His-tagged VEGFR-1 extracellular domain expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Umr 8638 Cnrs

Curated by ChEMBL
LigandPNGBDBM50521337(CHEMBL4592007)
Affinity DataKd:  6.21E+5nMAssay Description:Binding affinity to 15N-labeled VEGFR1 domain 2 (unknown origin) at 26 mM by TROSY [1H-15N] spectroscopic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed