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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50195222
Substrate
n/a
Meas. Tech.
ChEMBL_1617467 (CHEMBL3859536)
IC50
150000±n/a nM
Citation
 Cottet, K; Xu, B; Coric, P; Bouaziz, S; Michel, S; Vidal, M; Lallemand, MC; Broussy, S Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity. J Med Chem 59:9560-9566 (2016) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50195222
Synonyms:
CHEMBL3894424
Type:
Small organic molecule
Emp. Form.:
C30H36O6
Mol. Mass.:
492.6032
SMILES:
[#6]-[#8]-[#6]1=[#6](-[#6](=O)-c2ccccc2)-[#6](=O)[C@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6]-[#6@@H](-[#6](-[#8])=O)C([#6])([#6])[C@@]1([#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O |r,c:2,TLB:35:34:25.20.21:2.12.3|
Structure:
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