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Found 75 with Last Name = 'browne' and Initial = 'lj'
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM10044((2S,15S)-15-methyl-2-[(methylsulfanyl)methyl]tetra...)
Affinity DataKi:  1nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM9460(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Affinity DataKi:  470nMAssay Description:Competitive inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataIC50:  0.0300nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50368174(CHEMBL1203762)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025953(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid | CGS-1...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibitory activity against thromboxane A2 synthetase with lysed human platelets as the enzyme source.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027751(1-(4-Carboxy-2-methyl-6-phenyl-hexanoyl)-2,3-dihyd...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025970(6-Imidazo[1,5-a]pyridin-5-yl-hex-2-enoic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025966(7-Imidazo[1,5-a]pyridin-5-yl-heptanoic acid | CHEM...)
Affinity DataIC50:  5.20nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataIC50:  6.40nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50368173(CHEMBL1203766)
Affinity DataIC50:  7.60nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025952(5-[4-(1H-Tetrazol-5-yl)-butyl]-imidazo[1,5-a]pyrid...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50008726(CHEMBL348913 | [4-(5,6,7,8-Tetrahydro-imidazo[1,5-...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50008725(4-(6,7,8,9-Tetrahydro-5H-imidazo[1,5-a]azepin-5-yl...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50008729(1-(4-Cyanobenzyl)-5-methyl-1H-imidazole | 4-(5-Met...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50008733(1-(4-Cyanobenzyl)-1H-imidazole | 4-((1H-imidazol-1...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50368172(CHEMBL1203757)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025951(8-Imidazo[1,5-a]pyridin-5-yl-2-methyl-oct-2-enoic ...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025955(5-[5-(1H-Tetrazol-5-yl)-pentyl]-imidazo[1,5-a]pyri...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025967(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid hydroxy...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025961(8-Imidazo[1,5-a]pyridin-5-yl-octanoic acid | CHEMB...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50368175(CHEMBL1203760)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027764(1-(4-Carboxy-2-methyl-pentanoyl)-2,3-dihydro-1H-in...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025965(5-Imidazo[1,5-a]pyridin-5-yl-penta-2,4-dienoic aci...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027749(1-(4-Carboxy-6-phenyl-hexanoyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  33nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataIC50:  39nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027742(1-(4-Carboxy-6-phenyl-hexanoyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  39nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataIC50:  39nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025954(8-Imidazo[1,5-a]pyridin-5-yl-oct-2-enoic acid | CH...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025959(5-Imidazo[1,5-a]pyridin-5-yl-pentanoic acid | CHEM...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027754(1-(4-Carboxy-2-methyl-butyryl)-2,3-dihydro-1H-indo...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027755(1-[2-(2-Carboxy-ethyl)-3-methyl-butyryl]-2,3-dihyd...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027750(1-(4-Carboxy-2-methyl-pentanoyl)-2,3-dihydro-1H-in...)
Affinity DataIC50:  54nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027747(1-(4-Carboxy-2-methyl-butyryl)-2,3-dihydro-1H-indo...)
Affinity DataIC50:  64nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025969(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid amide |...)
Affinity DataIC50:  77nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50008724(4-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-5-yl)-...)
Affinity DataIC50:  93nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027762(1-(4-Carboxy-2-methyl-pentanoyl)-5-methoxy-2,3-dih...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027750(1-(4-Carboxy-2-methyl-pentanoyl)-2,3-dihydro-1H-in...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027765(1-(4-Carboxy-butyryl)-2,3-dihydro-1H-indole-2-carb...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025964(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid methyla...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025960(6-Imidazo[1,5-a]pyridin-5-yl-hexan-1-ol; hydrochlo...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027763(1-(3-Carboxy-2-methyl-propionyl)-2,3-dihydro-1H-in...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025957(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid ethyl e...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025971(5-Imidazo[1,5-a]pyridin-8-yl-pentanoic acid | CHEM...)
Affinity DataIC50:  390nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027748(1-(4-Carboxy-2-methyl-pentanoyl)-5-chloro-2,3-dihy...)
Affinity DataIC50:  440nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027741(1-(4-Carboxy-2-methyl-pentanoyl)-5-methyl-2,3-dihy...)
Affinity DataIC50:  490nMAssay Description:In vitro inhibition of angiotensin converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025958(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid dimethy...)
Affinity DataIC50:  550nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025968(6-Imidazo[1,5-a]pyridin-5-yl-hexanenitrile; hydroc...)
Affinity DataIC50:  630nMAssay Description:In vitro inhibition of thromboxane A2 synthetase from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027745(1-(4-Carboxy-pentanoyl)-2,3-dihydro-1H-indole-2-ca...)
Affinity DataIC50:  920nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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