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Found 744 with Last Name = 'brust' and Initial = 'p'
TargetVesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL
LigandPNGBDBM50039623((2R,3R)-5-Amino-3-(4-phenyl-piperidin-1-yl)-1,2,3,...)
Affinity DataKi:  0.0130nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL
LigandPNGBDBM50039613((2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrah...)
Affinity DataKi:  0.0550nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50361993(CHEMBL1939700)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 180 mins by solid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50259004(1'-[4-Fluorobenzyl]-3H-spiro[[2]benzofuran-1,4'pip...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Mahidol University

Curated by ChEMBL
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]A-585539 from alpha7 nAChR in human cerebral cortex membranes after 75 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50218673(2-(2-((dimethylamino)methyl)-4-fluorophenylthio)-5...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50218674(3-amino-4-(2-((dimethylamino)methyl)-4-fluoropheny...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]citalopram from SERT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50366029(CHEMBL1956465)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to VAchTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL
LigandPNGBDBM50095010(CHEMBL264437)
Affinity DataKi:  0.340nMAssay Description:Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50218670(5-chloro-2-(2-((dimethylamino)methyl)-4-fluorophen...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in quinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL
LigandPNGBDBM50600964(CHEMBL5181335)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-WIN55212-2 from human CB2 receptor transfected in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50343621(1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-nitrobenzyl)pi...)
Affinity DataKi:  0.430nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50046952((3'R,4'R)-1'-(4-Fluoro-benzyl)-4-phenyl-[1,3']bipi...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to VAchTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Abx Advanced Biochemical Compounds

Curated by ChEMBL
LigandPNGBDBM86522(CAS_325715-02-4 | Indiplon)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]Ro15-1788 from GABAA alpha1 receptor in Sprague-Dawley rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Abx Advanced Biochemical Compounds

Curated by ChEMBL
LigandPNGBDBM86522(CAS_325715-02-4 | Indiplon)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]Ro15-1788 from GABAA alpha-1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50299285(1'-Cyclohexylmethyl-3-(3-fluoropropyl)-3H-spiro[[2...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane after 180 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334161(1'-(4-fluorobenzyl)-3-(2-fluoroethyl)-3H-spiro[iso...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50259004(1'-[4-Fluorobenzyl]-3H-spiro[[2]benzofuran-1,4'pip...)
Affinity DataKi:  0.580nMAssay Description:Displacement of (+)-[3H]pentazocine from rat brain sigma1 receptor by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 180 mins by solid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL
LigandPNGBDBM50600961(CHEMBL5198892)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-SR141716A from recombinant human CB1 receptor expressed in CHO cells membrane incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL
LigandPNGBDBM50600966(CHEMBL5205138)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human CB2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL
LigandPNGBDBM50326618(CHEMBL1254015 | [11C]-3-(2-methoxyethyl)-4,5-dimet...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity to human cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50058020(4-[1-((E)-3-Iodo-allyl)-piperidin-4-ylmethoxy]-ben...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity to human brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334163(1'-(Cyclohexylmethyl)-3-(2-fluoroethyl)-3H-spiro[[...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50361998(CHEMBL1939698)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 180 mins by solid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50343619(1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-bromobenzyl)pi...)
Affinity DataKi:  0.780nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50259001(1'-(4-Fluorobenzyl)-3-methoxy-3H-spiro[[2]benzofur...)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50432550(CHEMBL2347001)
Affinity DataKi:  0.790nMAssay Description:Displacement of (+)-[3H]pentazocine from rat brain sigma1 receptor by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50343620(1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-iodobenzyl)pip...)
Affinity DataKi:  0.800nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50343618(1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-fluorobenzyl)p...)
Affinity DataKi:  0.850nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50258915(1'-(4-Fluorobenzyl)-3H-spiro[[2]benzofuran-1,4'-pi...)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf (Hzdr)

Curated by ChEMBL
LigandPNGBDBM50600965(CHEMBL5182619)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-WIN55212-2 from human CB2 receptor transfected in CHO-K1 cell membrane incubated for 90 mins by Liquid scintillation counter ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50343622(1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methylbenzyl)-...)
Affinity DataKi:  0.910nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Torpedo californica)
Institute Of Radiopharmaceutical Cancer Research

Curated by ChEMBL
LigandPNGBDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)
Affinity DataKi:  1nMAssay Description:Binding affinity to VAChT Torpedo californica electric organ synaptic vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Mahidol University

Curated by ChEMBL
LigandPNGBDBM92878(Quinuclidine analogue, 5)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50299280(1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofura...)
Affinity DataKi: >1nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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