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Found 345 with Last Name = 'bryans' and Initial = 'j'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50256615((R)-3-fluoro-1-((5-fluoro-1-(1H-imidazol-2-yl)-2,3...)
Affinity DataKi:  5nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50256563((R)-2-(5-chloro-4-(methoxymethyl)-2,3-dihydro-1H-i...)
Affinity DataKi:  83nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354912(CHEMBL1837039)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354897(CHEMBL1837041)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401913(CHEMBL2207214)
Affinity DataIC50:  2nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401928(CHEMBL2207195)
Affinity DataIC50:  2nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401907(CHEMBL2207181)
Affinity DataIC50:  2nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401915(CHEMBL2207212)
Affinity DataIC50:  2nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401927(CHEMBL2207199)
Affinity DataIC50:  3nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401903(CHEMBL2207194)
Affinity DataIC50:  3nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354913(CHEMBL1837028)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354895(CHEMBL1837038)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482266(US10918645, Example 65)
Affinity DataIC50:  4nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401914(CHEMBL2207213)
Affinity DataIC50:  4nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401918(CHEMBL2207209)
Affinity DataIC50:  4nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354896(CHEMBL1837040)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401910(CHEMBL2207217)
Affinity DataIC50:  6nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401902(CHEMBL2207196)
Affinity DataIC50:  6nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401900(CHEMBL2207198)
Affinity DataIC50:  6nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482288(8-ethyl-4-(tetrahydro-2H-pyran-4- yl)-5,11-dihydro...)
Affinity DataIC50:  6nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50:  6.70nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401922(CHEMBL2207204)
Affinity DataIC50:  7nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401920(CHEMBL2207206)
Affinity DataIC50:  7nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401911(CHEMBL2207216)
Affinity DataIC50:  7nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482268(US10918645, Example 66 | US10918645, Example 67)
Affinity DataIC50:  7nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401917(CHEMBL2207210)
Affinity DataIC50:  7nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401899(CHEMBL2207208)
Affinity DataIC50:  8nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401906(CHEMBL2207187)
Affinity DataIC50:  8nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401908(CHEMBL2207180)
Affinity DataIC50:  8nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401901(CHEMBL2207197)
Affinity DataIC50:  8nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401924(CHEMBL2207202)
Affinity DataIC50:  9nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401912(CHEMBL2207215)
Affinity DataIC50:  9nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354914(CHEMBL1837017)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401909(CHEMBL2207218)
Affinity DataIC50:  9nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401916(CHEMBL2207211)
Affinity DataIC50:  10nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401905(CHEMBL2207192)
Affinity DataIC50:  11nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482275(1-methyl-9-(tetrahydro-2H-pyran- 4-yl)-1,5,9,10-te...)
Affinity DataIC50:  11nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482286(8-methyl-4-(tetrahydro-2H-pyran-4- yl)-5,11-dihydr...)
Affinity DataIC50:  12nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP/microtubule affinity-regulating kinase 3(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401900(CHEMBL2207198)
Affinity DataIC50:  12nMAssay Description:Inhibition of MARK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401926(CHEMBL2207200)
Affinity DataIC50:  13nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482290(8-isopropyl-4-(tetrahydro-2H-pyran- 4-yl)-5,11-dih...)
Affinity DataIC50:  13nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50114031((2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401925(CHEMBL2207201)
Affinity DataIC50:  15nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482277(2-ethyl-9-(tetrahydro-2H-pyran-4- yl)-2,5,9,10-tet...)
Affinity DataIC50:  15nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50401921(CHEMBL2207205)
Affinity DataIC50:  16nMAssay Description:Inhibition of TBK1 by radiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Lifearc

US Patent
LigandPNGBDBM482283(1-isopropyl-9-(tetrahydro-2H- pyran-4-yl)-1,5,9,10...)
Affinity DataIC50:  16nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354916(CHEMBL1837031)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354915(CHEMBL1837022)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354917(CHEMBL1837027)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305900((+)-2-((1S,5S,6R)-6-(aminomethyl)bicyclo[3.2.0]hep...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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