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Found 98 with Last Name = 'bubenik' and Initial = 'm'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50:  0.000920nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123246((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidino-phen...)
Affinity DataIC50:  0.00130nMAssay Description:Inhibition of vitronectin binding to HT-29 cells expressing integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50:  0.00580nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591018(CHEMBL5204203)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123253((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123249((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidino-phen...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591016(CHEMBL5175156)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123252((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidino-phen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alpha5-beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591017(CHEMBL5206022)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591022(CHEMBL5197367)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of N-terminal His8-tagged/C-terminal FLAG-tagged full length human DNA polymerase theta ( 1 to 2590 residues) polymerase activity expresse...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123249((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidino-phen...)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of vitronectin binding to HT-29 cells expressing integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591030(CHEMBL5174509)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591026(CHEMBL5197173)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591015(CHEMBL5170373)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591028(CHEMBL5194637)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591027(CHEMBL5197021)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123249((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidino-phen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591019(CHEMBL5187337)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591024(CHEMBL5188048)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591033(CHEMBL5181369)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591029(CHEMBL5174376)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123250((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidinomethy...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alpha5-beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591032(CHEMBL5200250)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591021(CHEMBL5174283)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591020(CHEMBL5195161)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123253((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of vitronectin binding to HT-29 cells expressing integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591023(CHEMBL5194194)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591034(CHEMBL5206029)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591031(CHEMBL5202450)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123250((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidinomethy...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123249((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidino-phen...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591002(CHEMBL5195920)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 1 nM of enzyme concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591002(CHEMBL5195920)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 0.5 nM of enzyme concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591002(CHEMBL5195920)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 2 nM of enzyme concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591025(CHEMBL5200171)
Affinity DataIC50:  9nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591002(CHEMBL5195920)
Affinity DataIC50:  10nMAssay Description:Inhibition of human DNA polymerase theta using 5'-CACTGACTGTATGATG as primer and DNA 16/19 as substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123253((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...)
Affinity DataIC50:  11nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alpha5-beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123253((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...)
Affinity DataIC50:  11nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591002(CHEMBL5195920)
Affinity DataIC50:  11nMAssay Description:Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 5 nM of enzyme concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591014(CHEMBL5178605)
Affinity DataIC50:  14nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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