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Found 77 with Last Name = 'burgos' and Initial = 'a'
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190793(CHEMBL268939 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190791(CHEMBL210865 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190789(CHEMBL208565 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190784(CHEMBL378496 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161753(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of methyllycaconitine (MLA) binding to Nicotinic acetylcholine receptor alpha-7 in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190790(CHEMBL214195 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190794(CHEMBL211572 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Rattus norvegicus (Rat))
Hospital Saint-Antoine

Curated by PDSP Ki Database
LigandPNGBDBM50248034(2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-ph...)
Affinity DataKi:  124nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  174nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  188nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  310nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  511nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  580nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  628nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  663nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  962nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  1.66E+3nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161753(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.66E+3nMAssay Description:Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  4.54E+3nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161753(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  4.54E+3nMAssay Description:Functional antagonism of rat 5-hydroxytryptamine 3 receptor in cell-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28356((3R)-1-methyl-3-[(10R)-9-oxa-2-thiatricyclo[9.4.0....)
Affinity DataIC50:  1.15E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28356((3R)-1-methyl-3-[(10R)-9-oxa-2-thiatricyclo[9.4.0....)
Affinity DataIC50:  1.46E+4nMAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28347(3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2....)
Affinity DataIC50:  2.18E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28346(1-[(9S)-6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pent...)
Affinity DataIC50:  2.91E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28341((9aR)-2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxo...)
Affinity DataIC50:  3.19E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28341((9aR)-2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxo...)
Affinity DataIC50:  3.54E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28346(1-[(9S)-6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pent...)
Affinity DataIC50:  3.60E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28357(ZINC00347760, 26 | {3-[(10S)-2,9-dithiatricyclo[9....)
Affinity DataIC50:  3.67E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28357(ZINC00347760, 26 | {3-[(10S)-2,9-dithiatricyclo[9....)
Affinity DataIC50:  3.73E+4nMAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of alpha3beta4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28359(1-benzyl-4-[(E)-[(1-cyclohexyl-2,4,6-trioxo-1,3-di...)
Affinity DataIC50:  4.52E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28349(N-methyl-N-({[2-(phenylsulfanyl)phenyl]carbamoyl}m...)
Affinity DataIC50:  4.69E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28347(3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2....)
Affinity DataIC50:  5.43E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28349(N-methyl-N-({[2-(phenylsulfanyl)phenyl]carbamoyl}m...)
Affinity DataIC50:  5.63E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Alberta

LigandPNGBDBM28358((2R,7S)-18-chloro-3,3-dimethyl-14-thia-3-azatetrac...)
Affinity DataIC50:  5.87E+4nMAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of alpha1beta1gammadelta nAChR expressed in TE671cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of alpha3beta4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28358((2R,7S)-18-chloro-3,3-dimethyl-14-thia-3-azatetrac...)
Affinity DataIC50:  7.53E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28345(1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]...)
Affinity DataIC50:  7.87E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibition of alpha3beta4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Alberta

LigandPNGBDBM28354(2-{6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-y...)
Affinity DataIC50:  8.44E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of TryR was carried out in 96-well plates using a Biotek Precision 2000 automated liquid handler. Reaction was initiated by addition of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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