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Found 164 with Last Name = 'butcher' and Initial = 'k'
TargetCarboxypeptidase B(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  0.420nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase N catalytic chain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma carboxypeptidase NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  4nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  10nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50109593(2-Benzyl-3-mercapto-propionic acid | 2-Mercaptomet...)
Affinity DataKi:  11nMAssay Description:Inhibition of bovine pancreatic carboxypeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226605((+/-)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl...)
Affinity DataKi:  46nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226598((S)-2-(2-aminoethylamino)-3-(1-butyl-1H-imidazol-4...)
Affinity DataKi:  70nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  84nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226597((S)-2-(2-aminoethylamino)-3-(1-isobutyl-1H-imidazo...)
Affinity DataKi:  100nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226611((S)-2-(2-aminoethylamino)-3-(1-(3-hydroxypropyl)-1...)
Affinity DataKi:  111nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226614((S)-2-(2-aminoethylamino)-3-(1-(cyclobutylmethyl)-...)
Affinity DataKi:  124nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226613((S)-2-(2-aminoethylamino)-3-(1-phenethyl-1H-imidaz...)
Affinity DataKi:  140nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226607((+/-)-2-((1H-imidazol-4-yl)methyl)-5-aminopentanoi...)
Affinity DataKi:  140nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226602((S)-2-(2-aminoethylamino)-3-(1-pentyl-1H-imidazol-...)
Affinity DataKi:  160nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  206nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226601((2S)-2-[(2-aminoethyl)amino]-3-(1-methyl-1H-imidaz...)
Affinity DataKi:  235nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226599((S)-2-(2-aminoethylamino)-3-(1-ethyl-1H-imidazol-4...)
Affinity DataKi:  250nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226608((S)-2-(2-aminoethylamino)-3-(1-benzyl-1H-imidazol-...)
Affinity DataKi:  269nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226603((+/-)-5-amino-2-(mercaptomethyl)pentanoic acid | C...)
Affinity DataKi:  300nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226600((2S)-2-[(2-aminoethyl)amino]-3-(1H-imidazol-4-yl)p...)
Affinity DataKi:  344nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226609((S)-2-(2-aminoethylamino)-3-(1-isopropyl-1H-imidaz...)
Affinity DataKi:  430nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226604(CHEMBL392205 | ent-(2S)-5-amino-2-[(1-n-propyl-1H-...)
Affinity DataKi: >700nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase N catalytic chain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226600((2S)-2-[(2-aminoethyl)amino]-3-(1H-imidazol-4-yl)p...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human plasma carboxypeptidase NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226612((R)-2-(2-aminoethylamino)-3-(1H-imidazol-4-yl)prop...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257167(CHEMBL2325619)
Affinity DataIC50:  2nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257179(CHEMBL2325622)
Affinity DataIC50:  3nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257166(CHEMBL2325330)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257216(CHEMBL2325350)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMisshapen-like kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361467(CHEMBL1938400)
Affinity DataIC50:  6nMAssay Description:Inhibition of MINKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257180(CHEMBL2325317)
Affinity DataIC50:  7nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257178(CHEMBL2325627)
Affinity DataIC50:  8nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257214(CHEMBL2325601)
Affinity DataIC50:  9nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257168(CHEMBL2325013)
Affinity DataIC50:  9nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257181(CHEMBL2325020)
Affinity DataIC50:  10nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257211(CHEMBL2325038)
Affinity DataIC50:  11nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  11nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257212(CHEMBL2325021)
Affinity DataIC50:  13nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257183(CHEMBL2324755)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257182(CHEMBL2324753)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257175(CHEMBL2324776)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361467(CHEMBL1938400)
Affinity DataIC50:  23nMAssay Description:Inhibition of p38beta MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257176(CHEMBL2324396)
Affinity DataIC50:  26nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257216(CHEMBL2325350)
Affinity DataIC50: <30nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257165(CHEMBL2324391)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257210(CHEMBL2324742)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257215(CHEMBL2324411)
Affinity DataIC50:  31nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257213(CHEMBL2325016)
Affinity DataIC50:  31nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257164(CHEMBL2324405)
Affinity DataIC50:  34nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257213(CHEMBL2325016)
Affinity DataIC50:  36nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257164(CHEMBL2324405)
Affinity DataIC50:  37nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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