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Target
Carboxypeptidase N catalytic chain
Ligand
BDBM50201438
Substrate
n/a
Meas. Tech.
ChEMBL_452078 (CHEMBL901239)
Ki
2±n/a nM
Citation
 Bunnage, ME; Blagg, J; Steele, J; Owen, DR; Allerton, C; McElroy, AB; Miller, D; Ringer, T; Butcher, K; Beaumont, K; Evans, K; Gray, AJ; Holland, SJ; Feeder, N; Moore, RS; Brown, DG Discovery of potent& selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem 50:6095-103 (2007) [PubMed]  Article 
Target
Name:
Carboxypeptidase N catalytic chain
Synonyms:
ACBP | Anaphylatoxin inactivator | Arginine carboxypeptidase | CBPN_HUMAN | CPN | CPN1 | Carboxypeptidase N catalytic chain | Carboxypeptidase N polypeptide 1 | Carboxypeptidase N small subunit | Carboxypeptidase N, catalytic subunit | Kininase-1 | Lysine carboxypeptidase | Plasma carboxypeptidase B | SCPN | Serum carboxypeptidase N
Type:
PROTEIN
Mol. Mass.:
52293.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1496379
Residue:
458
Sequence:
MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
  
Inhibitor
Name:
BDBM50201438
Synonyms:
(+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid | 5-guanidino-2-(mercaptomethyl)pentanoic acid | CHEMBL236822
Type:
Small organic molecule
Emp. Form.:
C7H15N3O2S
Mol. Mass.:
205.278
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6](-[#6]-[#16])-[#6](-[#8])=O
Structure:
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