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Found 449 with Last Name = 'by' and Initial = 'y'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246934((S)-2-(3-((S)-1-carboxy-5-(4-fluorobenzamido)penty...)
Affinity DataKi:  0.194nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246934((S)-2-(3-((S)-1-carboxy-5-(4-fluorobenzamido)penty...)
Affinity DataKi:  0.256nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246935((S)-2-(3-((S)-1-carboxy-5-(3-iodonicotinamido)pent...)
Affinity DataKi:  0.351nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246935((S)-2-(3-((S)-1-carboxy-5-(3-iodonicotinamido)pent...)
Affinity DataKi:  0.557nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135269(CHEMBL3745775)
Affinity DataKi:  0.830nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135268(CHEMBL3747482)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  1.08nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Aix-Marseille Universit£

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50032936(CHEMBL3356589)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135270(CHEMBL3747468)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135275(CHEMBL3746517)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135274(CHEMBL404190)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Aix-Marseille Universit£

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304722((S)-2-(3-((S)-1-Carboxybut-3-ynyl)ureido)-6-(4-iod...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304731((S)-2-(3-((S)-1-Carboxy-2-(furan-2-yl)ethyl)ureido...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135269(CHEMBL3745775)
Affinity DataKi:  8nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50032936(CHEMBL3356589)
Affinity DataKi:  10nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135268(CHEMBL3747482)
Affinity DataKi:  11nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135270(CHEMBL3747468)
Affinity DataKi:  11nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304751((S)-2-(3-((S)-1-Carboxybut-3-enyl)ureido)-6-(4-iod...)
Affinity DataKi:  11nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Homo sapiens (Human))
Aix-Marseille Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  12.9nMAssay Description:Binding affinity to adenosine receptor A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304735((S)-2-(3-((S)-1-Carboxy-2-(thiazol-4-yl)ethyl)urei...)
Affinity DataKi:  16.1nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304732((S)-2-(3-((S)-1-Carboxy-2-(thiophen-2-yl)ethyl)ure...)
Affinity DataKi:  16.2nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50360218(CHEMBL1927827)
Affinity DataKi:  20nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135271(CHEMBL3747575)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50135272(CHEMBL3747618)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304727((S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureid...)
Affinity DataKi:  23nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304727((S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureid...)
Affinity DataKi:  23nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304728((S)-2-(3-((S)-4-(Acetylthio)-1-carboxybutyl)ureido...)
Affinity DataKi:  24.1nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50360217(CHEMBL1927829)
Affinity DataKi:  29nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304723((S)-2-(3-((S)-1-Carboxybutyl)ureido)-6-(4-iodobenz...)
Affinity DataKi:  52.3nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50360219(CHEMBL1927826)
Affinity DataKi:  56nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50360216(CHEMBL1927828)
Affinity DataKi:  72nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304715(2-(4-Hydroxy-3-methoxyphenyl)-2-(3-((S)-1-isopropo...)
Affinity DataKi:  81nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCaP cells by fluorescence based NAALADase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304729((S)-2-(3-((S)-Carboxy(4-hydroxyphenyl)methyl)ureid...)
Affinity DataKi:  85.1nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304737((S)-2-(3-((S)-1-carboxy-2-(pyridin-3-yl)ethyl)urei...)
Affinity DataKi:  97.2nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304736((S)-2-(3-((S)-1-Carboxy-2-(pyridin-4-yl)ethyl)urei...)
Affinity DataKi:  105nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50360220(CHEMBL1927825)
Affinity DataKi:  121nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304725((S)-2-(3-((S)-1-Carboxy-2-cyanoethyl)ureido)-6-(4-...)
Affinity DataKi:  132nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304723((S)-2-(3-((S)-1-Carboxybutyl)ureido)-6-(4-iodobenz...)
Affinity DataKi:  145nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCAP cells assessed as glutamate formation using NAAG as substrate after 60 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304714(2-(4-Hydroxy-3-methoxyphenyl)-2-(3-((S)-1-methoxy-...)
Affinity DataKi:  153nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCaP cells by fluorescence based NAALADase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135275(CHEMBL3746517)
Affinity DataKi:  177nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135274(CHEMBL404190)
Affinity DataKi:  227nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein homolog(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50135272(CHEMBL3747618)
Affinity DataKi:  246nMAssay Description:Inhibition of mouse recombinant matriptase using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304713((S)-2-(3-(Carboxy(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataKi:  250nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCaP cells by fluorescence based NAALADase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304724((2S)-2-(3-((1S)-1-carboxy-2-(oxiran-2-yl)ethyl)ure...)
Affinity DataKi:  254nMAssay Description:Inhibition of human cloned glutamate carboxypeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50304717(2-(4-Hydroxy-3-iodophenyl)-2-(3-((S)-1-isopropoxy-...)
Affinity DataKi:  275nMAssay Description:Inhibition of glutamate carboxypeptidase 2 in human LNCaP cells by fluorescence based NAALADase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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