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Found 104 with Last Name = 'canet' and Initial = 'e'
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290462(CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carba...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of the compound for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuromedin-K receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290462(CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carba...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound for NK-3 receptor was determined in vitro using isolated rat portal vein.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290461(CHEMBL65468 | potassium 3,5-di(trifluoromethyl)ben...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuromedin-K receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290461(CHEMBL65468 | potassium 3,5-di(trifluoromethyl)ben...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity of the compound for NK-3 receptor was determined in vitro using isolated rat portal vein.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290462(CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carba...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290461(CHEMBL65468 | potassium 3,5-di(trifluoromethyl)ben...)
Affinity DataKi:  9nMAssay Description:Binding affinity of the compound for NK-1 receptor was determined in vitro using isolated rabbit vena cava.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290461(CHEMBL65468 | potassium 3,5-di(trifluoromethyl)ben...)
Affinity DataKi:  9nMAssay Description:Antagonistic potency for NK-1 receptor was determined in a radioligand binding assay, using IM9 human lymphoblastoma cell line.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290462(CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carba...)
Affinity DataKi:  9.60nMAssay Description:Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290462(CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carba...)
Affinity DataKi:  2.40E+3nMAssay Description:Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290461(CHEMBL65468 | potassium 3,5-di(trifluoromethyl)ben...)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity of the compound for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058495(3-{2-[2-(Thiophene-2-carbonylsulfanyl)-propionylam...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058491(3-{4-[2-(4-{1-[4-(2-Carboxy-2-methyl-propane-1-sul...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045033(1N-[1-[1-benzyl(methyl)carbamoyl-2-phenyl-(1S)-eth...)
Affinity DataIC50:  6nMAssay Description:Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058493((R)-2-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045040(CHEMBL3144343 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  17nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058492((R)-1-{2-[4-(4-Chloro-benzenesulfonylaminocarbonyl...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058474((R)-2-(2-{4-[(6-Hydroxy-3,5,7,8-tetramethyl-chroma...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045036(7-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  21nMAssay Description:Tested for binding affinity against human NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058486((R)-2-(2-{4-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl...)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058480((R)-2-{2-[4-(4-Chloro-benzoylsulfamoyl)-benzoylami...)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058473((2R,3aR,7aR)-1-[2-(4-{4-Chloro-3-[2-(3,5-di-tert-b...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058475((R)-2-(2-{4-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058485(CHEMBL2373010 | {2-Methyl-1-[(R)-3-(3,3,3-trifluor...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50031201((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045039(6-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  34nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058489((2R,3aR,7aR)-1-[2-(4-{4-Chloro-3-[2-(3,5-di-tert-b...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058487((2R,3aR,7aR)-1-{2-[4-(3,5-Di-tert-butyl-4-hydroxy-...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058481((2R,3aR,7aR)-1-(2-{4-[(E)-3-(3,5-Di-tert-butyl-4-e...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058477((2R,3aR,7aR)-1-(2-{4-[2-(3,5-Di-tert-butyl-4-hydro...)
Affinity DataIC50:  38nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058471((2R,3aR,7aR)-1-(2-{4-[(E)-3-(3,5-Di-tert-butyl-4-h...)
Affinity DataIC50:  38nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058478((2R,3aR,7aR)-1-[2-(4-{4-[2-(3,5-Di-tert-butyl-4-hy...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058479(2,6-Dimethyl-4-[4-(4-{2-methyl-1-[(R)-3-(3,3,3-tri...)
Affinity DataIC50:  41nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058483((2R,3aR,7aR)-1-(2-{4-[2-(3,5-Di-tert-butyl-4-hydro...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045036(7-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  45nMAssay Description:Tested for binding affinity against human NK-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058494(3,5-Di-tert-butyl-4-hydroxy-benzoic acid 2,6-di-te...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058490((2R,3aR,7aR)-1-(2-{4-Chloro-3-[2-(3,5-di-tert-buty...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045039(6-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  46nMAssay Description:Tested for binding affinity against human NK-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045040(CHEMBL3144343 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  54nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058476((S)-1-[(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataIC50:  59nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rattus norvegicus (Rat))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045037(CHEMBL3144352 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  65nMAssay Description:Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045037(CHEMBL3144352 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  65nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058482((S)-1-{(R)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045032(CHEMBL3144353 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  79nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50058488((S)-1-{(R)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataIC50:  84nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045035(4-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  85nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045033(1N-[1-[1-benzyl(methyl)carbamoyl-2-phenyl-(1S)-eth...)
Affinity DataIC50:  99nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50199883(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Affinity DataIC50:  100nMAssay Description:The compound was evaluated in vitro for the inhibition of human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045032(CHEMBL3144353 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  127nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045035(4-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  129nMAssay Description:Tested for binding affinity against human NK-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rattus norvegicus (Rat))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045040(CHEMBL3144343 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  142nMAssay Description:Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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