Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50058495
Substrate
n/a
Meas. Tech.
ChEMBL_63796 (CHEMBL679049)
IC50
0.1±n/a nM
Citation
 Portevin, B; Lonchampt, M; Canet, E; De Nanteuil, G Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives. J Med Chem 40:1906-18 (1997) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50058495
Synonyms:
3-{2-[2-(Thiophene-2-carbonylsulfanyl)-propionylamino]-acetyl}-thiazolidine-4-carboxylic acid | CHEMBL293138
Type:
Small organic molecule
Emp. Form.:
C14H16N2O5S3
Mol. Mass.:
388.482
SMILES:
CC(SC(=O)c1cccs1)C(=O)NCC(=O)N1CSCC1C(O)=O
Structure:
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