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Found 152 with Last Name = 'cen' and Initial = 'x'
TargetMu-type opioid receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM518578(US11124523, Example (+)-16)
Affinity DataKi:  0.514nMAssay Description:Displacement of [3H]-Diprenorphine from human mu opiod receptor expressed in CHO cells incubated for 1 hr by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-Diprenorphine from human mu opiod receptor expressed in CHO cells incubated for 1 hr by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-Diprenorphine from human mu opiod receptor expressed in CHO cells incubated for 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420296(Advanced SARS-CoV-2 Inhibitor 11a | MPI10 | acs.jm...)
Affinity DataIC50:  53nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603136(CHEMBL5170470)
Affinity DataIC50:  170nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603134(CHEMBL5202967)
Affinity DataIC50:  240nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603133(CHEMBL5190525)
Affinity DataIC50:  460nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603135(CHEMBL5178161)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603152(CHEMBL5170772)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603150(CHEMBL5176974)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603148(CHEMBL5208533)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603151(CHEMBL5171053)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603140(CHEMBL5209481)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603149(CHEMBL5172623)
Affinity DataIC50:  2.78E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603154(CHEMBL5203602)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603142(CHEMBL5192799)
Affinity DataIC50:  3.57E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603139(CHEMBL5188663)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603138(CHEMBL5202748)
Affinity DataIC50:  3.76E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603161(CHEMBL5178951)
Affinity DataIC50:  3.78E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603155(CHEMBL5176381)
Affinity DataIC50:  4.12E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603159(CHEMBL5187485)
Affinity DataIC50:  4.22E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603147(CHEMBL5175443)
Affinity DataIC50:  4.24E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603156(CHEMBL5172881)
Affinity DataIC50:  4.25E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603143(CHEMBL5171351)
Affinity DataIC50:  4.44E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603145(CHEMBL5208115)
Affinity DataIC50:  4.57E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603137(CHEMBL5194068)
Affinity DataIC50:  4.64E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603153(CHEMBL5190081)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603160(CHEMBL5207943)
Affinity DataIC50:  4.74E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603158(CHEMBL5179446)
Affinity DataIC50:  5.21E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603141(CHEMBL5183915)
Affinity DataIC50:  5.36E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603146(CHEMBL5199583)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603144(CHEMBL5202723)
Affinity DataIC50:  6.25E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603162(CHEMBL5195683)
Affinity DataIC50:  6.58E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603163(CHEMBL5183898)
Affinity DataIC50:  6.86E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603157(CHEMBL5201381)
Affinity DataIC50:  6.97E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603168(CHEMBL5175506)
Affinity DataIC50:  8.05E+3nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 2, facilitated glucose transporter member 9(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603134(CHEMBL5202967)
Affinity DataIC50:  9.37E+3nMAssay Description:Inhibition of GLUT9 (unknown origin) expressed in HEK293T cells assessed as inhibition of uric acid-induced current by whole cell patch clamp techniq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603164(CHEMBL5204323)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603167(CHEMBL5202543)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603136(CHEMBL5170470)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by incubation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603169(CHEMBL5184930)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603166(CHEMBL5191628)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603165(CHEMBL5208873)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of URAT1 (unknown origin)-mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603136(CHEMBL5170470)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells membrane vesicles assessed as inhibition of ATP-induced 14C-uric acid uptake preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM518578(US11124523, Example (+)-16)
Affinity DataIC50:  2.28E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603133(CHEMBL5190525)
Affinity DataIC50:  2.55E+4nMAssay Description:Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by incubation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603134(CHEMBL5202967)
Affinity DataIC50:  2.67E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells membrane vesicles assessed as inhibition of ATP-induced 14C-uric acid uptake preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50603135(CHEMBL5178161)
Affinity DataIC50:  2.79E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells membrane vesicles assessed as inhibition of ATP-induced 14C-uric acid uptake preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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