Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM50603151
Substrate
n/a
Meas. Tech.
ChEMBL_2243233 (CHEMBL5157443)
IC50
2550±n/a nM
Citation
 Zhao, Z; Liu, J; Kuang, P; Luo, J; Surineni, G; Cen, X; Wu, T; Cao, Y; Zhou, P; Pang, J; Zhang, Q; Chen, J Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia. Eur J Med Chem 229:0 (2022) [PubMed] 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM50603151
Synonyms:
CHEMBL5171053
Type:
Small organic molecule
Emp. Form.:
C24H16N3NaO2S
Mol. Mass.:
433.458
SMILES:
[Na;v0+].[#8-]-[#6](=O)-c1ccc(-[#6]-[#16]-c2ccncc2-[#7]-c2ccc(C#N)c3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: