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Found 90 with Last Name = 'chapman' and Initial = 'kl'
TargetCholecystokinin(GUINEA PIG)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50040671(1-[5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholecystokinin(GUINEA PIG)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82514(1-[[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-[(hexahydro-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholecystokinin(GUINEA PIG)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(1-((S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataKi:  8.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50040671(1-[5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82514(1-[[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-[(hexahydro-...)
Affinity DataKi:  3.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50454480(CHEMBL2093059)
Affinity DataIC50:  0.0540nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50454481(CHEMBL2110201)
Affinity DataIC50:  0.0740nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059319(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049783(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049789(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50040666(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50454482(CHEMBL2110202)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049785(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50043493(CHEMBL313813 | N,N-Diethyl-2-[2-oxo-5-pyridin-2-yl...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049786(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286602((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 1-[(3-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049788(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059320(1-[(R)-5-((R)-4,4-Dimethyl-piperidin-2-yl)-2-oxo-1...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50040664(1-(5-Azepan-1-yl-1-methyl-2-oxo-2,3-dihydro-1H-ben...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286596((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 1-[(3-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059327(1-[(R)-5-((R)-4,4-Dimethyl-piperidin-2-yl)-2-oxo-1...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286595((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 4-dipe...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286598((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 2-({2-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286600(CHEMBL357757 | Carbamoylmethyl-[2-({(2S,4S)-1-[(3-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059325(1-[(R)-5-((R)-4,4-Dimethyl-piperidin-2-yl)-1-methy...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286597((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 2-{[2-...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286592((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 2-({2-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286601((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 2-[(3-...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049790(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049784(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286605((S)-Piperazine-1,2,4-tricarboxylic acid 1-[(3-chlo...)
Affinity DataIC50:  8nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50006878((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  8.5nMAssay Description:The concentration of the compound required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pigcorti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50006878((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040664(1-(5-Azepan-1-yl-1-methyl-2-oxo-2,3-dihydro-1H-ben...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ligand binding to Cholecystokinin type A receptor receptor from rat pancreatic tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059326(1-[(R)-5-((R)-5,5-Dimethyl-azepan-2-yl)-1-methyl-2...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286594((2S,4S)-Piperidine-1,2,4-tricarboxylic acid 2-{[2-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059322(1-[(R)-5-((R)-5,5-Dimethyl-azepan-2-yl)-2-oxo-1-pr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059324(2-[(R)-1-Diethylcarbamoylmethyl-2-oxo-3-(3-m-tolyl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286604((2S,4S)-1-[(3-Chloro-phenyl)-phenyl-carbamoyl]-4-d...)
Affinity DataIC50:  20nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049787(1-{4-Methyl-3-[methyl-(1H-tetrazol-5-yl)-amino]-ph...)
Affinity DataIC50:  20nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059329(1-[(R)-2-Oxo-1-propyl-5-((R)-1,5,5-trimethyl-azepa...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286603((2S,4S)-4-Dipentylcarbamoyl-1-diphenylcarbamoyl-pi...)
Affinity DataIC50:  33nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059328(1-((R)-2-Oxo-5-(R)-piperidin-2-yl-1-propyl-2,3-dih...)
Affinity DataIC50:  36nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281187((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(3-diet...)
Affinity DataIC50:  41nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059323(1-((R)-2-Oxo-5-(S)-piperidin-2-yl-1-propyl-2,3-dih...)
Affinity DataIC50:  41nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059321(1-[(R)-5-((R)-1-Methyl-piperidin-2-yl)-2-oxo-1-pro...)
Affinity DataIC50:  54nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50043500(1-(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-be...)
Affinity DataIC50:  65nMAssay Description:Inhibition of ligand binding to Cholecystokinin type A receptor receptor from rat pancreatic tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50043500(1-(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-be...)
Affinity DataIC50:  66nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286599((2S,4R)-Piperidine-1,2,4-tricarboxylic acid 4-dipe...)
Affinity DataIC50:  73nMAssay Description:Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
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