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Found 268 with Last Name = 'charton' and Initial = 'j'
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172914((S)-2-(2-Piperidin-1-yl-ethyl)-3-thioxo-2,3,10,10a...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382480(CHEMBL2022215)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382484(CHEMBL2022213)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382483(CHEMBL2022212)
Affinity DataIC50:  2nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172886((S)-2-[3-(Methyl-phenethyl-amino)-propyl]-10,10a-d...)
Affinity DataIC50:  2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172884((S)-2-(1-Benzyl-piperidin-4-yl)-10,10a-dihydro-5H-...)
Affinity DataIC50:  2.40nMpH: 7.5 T: 2°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172874((S)-2-{2-[Methyl-(5-phenyl-pentyl)-amino]-ethyl}-1...)
Affinity DataIC50:  2.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382482(CHEMBL2022214)
Affinity DataIC50:  3nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172869((S)-2-{2-[Methyl-(4-phenyl-butyl)-amino]-ethyl}-10...)
Affinity DataIC50:  3.20nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172868((S)-2-(3-(benzyl(methyl)amino)propyl)-10,10a-dihyd...)
Affinity DataIC50:  3.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50525490(CHEMBL4437643)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172875((S)-2-[4-(Benzyl-methyl-amino)-butyl]-10,10a-dihyd...)
Affinity DataIC50:  4.20nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172881((S)-2-[2-(Benzyl-methyl-amino)-ethyl]-10,10a-dihyd...)
Affinity DataIC50:  4.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50126458((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-benzyl-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172880((S)-2-[5-(Benzyl-methyl-amino)-pentyl]-10,10a-dihy...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172877((S)-2-(2-Piperidin-1-yl-ethyl)-10,10a-dihydro-5H-i...)
Affinity DataIC50:  6.60nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382485(CHEMBL2022209)
Affinity DataIC50:  7nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172887((S)-2-[6-(Benzyl-methyl-amino)-hexyl]-10,10a-dihyd...)
Affinity DataIC50:  9.40nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172871((S)-2-(3-Benzylamino-propyl)-10,10a-dihydro-5H-imi...)
Affinity DataIC50:  9.60nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172876((S)-2-[4-(Methyl-phenethyl-amino)-butyl]-10,10a-di...)
Affinity DataIC50:  9.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172873((S)-2-[3-(4-Phenyl-butylamino)-propyl]-10,10a-dihy...)
Affinity DataIC50:  10.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172893((S)-2-[5-(Methyl-phenethyl-amino)-pentyl]-10,10a-d...)
Affinity DataIC50:  11.7nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172867((S)-2-[2-(Methyl-phenethyl-amino)-ethyl]-10,10a-di...)
Affinity DataIC50:  12.6nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172888((S)-2-{2-[Methyl-(3-phenyl-propyl)-amino]-ethyl}-1...)
Affinity DataIC50:  13.6nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172877((S)-2-(2-Piperidin-1-yl-ethyl)-10,10a-dihydro-5H-i...)
Affinity DataIC50:  16nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172877((S)-2-(2-Piperidin-1-yl-ethyl)-10,10a-dihydro-5H-i...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172879((S)-2-(3-Piperidin-1-yl-propyl)-10,10a-dihydro-5H-...)
Affinity DataIC50:  21.5nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172879((S)-2-(3-Piperidin-1-yl-propyl)-10,10a-dihydro-5H-...)
Affinity DataIC50:  21.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172889((S)-2-[3-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-...)
Affinity DataIC50:  23.8nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382481(CHEMBL2022219)
Affinity DataIC50:  28nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172885((S)-2-[6-(Methyl-phenethyl-amino)-hexyl]-10,10a-di...)
Affinity DataIC50:  29.5nMpH: 7.5 T: 2°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172872((S)-2-[3-(4-Benzyl-piperazin-1-yl)-propyl]-10,10a-...)
Affinity DataIC50:  32nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Mus musculus (Mouse))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50:  50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172912((S)-2-(2-Piperidin-1-yl-ethyl)-1,5,10,10a-tetrahyd...)
Affinity DataIC50:  54nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50382479(CHEMBL2022222)
Affinity DataIC50:  56nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50:  60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172911((S)-2-(3-Piperidin-1-yl-propyl)-9,9a-dihydro-imida...)
Affinity DataIC50:  66nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172915((S)-2-(2-Piperidin-1-yl-ethyl)-1,2,3,5,10,10a-hexa...)
Affinity DataIC50:  77nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Lille 2

Curated by ChEMBL
LigandPNGBDBM50197498(CHEMBL220311 | N-hydroxy-2-isobutyl-N'-(4-phenyl-b...)
Affinity DataIC50:  82nMAssay Description:Inhibition of microsomal neural aminopeptidase in pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172891((S)-2-[3-(1-Benzyl-piperidin-4-ylamino)-propyl]-10...)
Affinity DataIC50:  82.3nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50172895((S)-2-[3-(4-Methyl-piperazin-1-yl)-propyl]-10,10a-...)
Affinity DataIC50: >100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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