Compile Data Set for Download or QSAR
maximum 50k data
Found 27 with Last Name = 'chellaraj' and Initial = 'v'
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156460(3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbonyl]...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156459(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  59nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  88nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataIC50:  480nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates tolbutamide (2C9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against human Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataIC50:  2.19E+3nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates s-mephenytoin (2C19)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50:  5.38E+3nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates tolbutamide (2C9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates s-mephenytoin (2C19)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50:  1.71E+4nMAssay Description:Inhibitory activity against human Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156460(3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbonyl]...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory activity against human Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates s-mephenytoin (2C19)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates tolbutamide (2C9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataIC50:  7.68E+4nMAssay Description:Inhibitory activity against human Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467054(CHEMBL4288731)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467055(CHEMBL4283963)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467056(CHEMBL4287326)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467057(CHEMBL4295230)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467058(CHEMBL4278070)
Affinity DataEC50:  314nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467052(CHEMBL4279401)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467057(CHEMBL4295230)
Affinity DataEC50:  274nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467058(CHEMBL4278070)
Affinity DataEC50:  1.36E+3nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467054(CHEMBL4288731)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467053(CHEMBL4290744)
Affinity DataEC50:  159nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467052(CHEMBL4279401)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467053(CHEMBL4290744)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed