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Found 69 with Last Name = 'chelur' and Initial = 's'
TargetAndrogen receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50057651(CHEMBL3326454)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]DHT from androgen receptor in human MDA-MB-435 cells after 30 minsMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547958(CHEMBL4789918)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547947(CHEMBL4760206)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547949(CHEMBL4743091)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547959(CHEMBL4750630)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547962(CHEMBL4784665)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547955(CHEMBL4796558)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547954(CHEMBL4763990)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547953(CHEMBL4790506)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547961(CHEMBL4777409)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547946(CHEMBL4757687)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547963(CHEMBL4757349)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547948(CHEMBL4742305)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547950(CHEMBL4748475)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547965(CHEMBL4741488)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200372(US10011599, Example 1A | US9227969, 1A | US9629836...)
Affinity DataIC50:  25nMAssay Description:Inhibition of wild-type human partial length TRKA (G475 to G790 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547952(CHEMBL4757094)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547956(CHEMBL4748082)
Affinity DataIC50:  55nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547947(CHEMBL4760206)
Affinity DataIC50:  59nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547960(CHEMBL4755398)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585940(CHEMBL5090765)
Affinity DataIC50:  70nMAssay Description:Inhibition of full-length human MEK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585939(CHEMBL5094993)
Affinity DataIC50:  100nMAssay Description:Inhibition of full-length human MEK1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547948(CHEMBL4742305)
Affinity DataIC50:  103nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547951(CHEMBL4791469)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547965(CHEMBL4741488)
Affinity DataIC50:  233nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  270nMAssay Description:Inhibition of IRAK4 in human MV4-11 cells assessed as modulation of phospho-IRAK1 level by immunoblotting analysisMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547945(CHEMBL4790504)
Affinity DataIC50:  397nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585939(CHEMBL5094993)
Affinity DataIC50: <500nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585942(CHEMBL5092411)
Affinity DataIC50: <500nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547957(CHEMBL4790895)
Affinity DataIC50:  505nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  514nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  696nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR5-mediated FLA-ST-induced IL-6 release preincubated for 1 hr followed by FLA-ST...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50057651(CHEMBL3326454)
Affinity DataIC50:  700nMAssay Description:Binding affinity to progesterone receptor (unknown origin) incubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547944(CHEMBL4788562)
Affinity DataIC50:  797nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  989nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR2-mediated LTA-induced IL-6 release preincubated for 1 hr followed by LTA stimu...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50057651(CHEMBL3326454)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity to estrogen receptor (unknown origin) incubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547967(CHEMBL4757221)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50057651(CHEMBL3326454)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) incubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547966(CHEMBL4747796)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585943(CHEMBL5076921)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of IL-1R-mediated IL-1beta-induced IL-6 release preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547943(CHEMBL4789126)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585941(CHEMBL5089865)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200455(US10011599, Example 84 | US9227969, 84)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200439(US10011599, Example 68 | US9227969, 68 | US9629836...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585938(CHEMBL5087942)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of full-length human MEK1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200425(US10011599, Example 52 | US9227969, 52)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50585945(CHEMBL5088062)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200372(US10011599, Example 1A | US9227969, 1A | US9629836...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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