Compile Data Set for Download or QSAR
maximum 50k data
Found 145 with Last Name = 'chu' and Initial = 'dt'
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50366826(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Affinity DataKi:  2.49E+3nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045000((NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-...)
Affinity DataKi:  3.13E+3nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataKi:  4.42E+3nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50226409(DEXTROFLOXACINE)
Affinity DataKi:  7.47E+4nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50366826(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Affinity DataKi:  9.96E+4nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045000((NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-...)
Affinity DataKi:  2.25E+5nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataKi:  2.32E+5nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50226409(DEXTROFLOXACINE)
Affinity DataKi:  2.90E+5nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: >1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: >1nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188945(CHEMBL379507 | N-(1-amino-3-(2,4-dichlorophenyl)pr...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  6nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  11nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188929(CHEMBL384964 | N-((S)-1-(2,4-dichlorophenyl)-3-(di...)
Affinity DataIC50:  11nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  12nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188927(CHEMBL385143 | N-((S)-4-amino-1-(2,4-dichloropheny...)
Affinity DataIC50:  27nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232913(CHEMBL4103350)
Affinity DataIC50:  58nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232926(CHEMBL4080017)
Affinity DataIC50:  65nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  66nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232920(CHEMBL4078432)
Affinity DataIC50:  67nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232912(CHEMBL4104843)
Affinity DataIC50:  68nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232924(CHEMBL4085424)
Affinity DataIC50:  72nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232913(CHEMBL4103350)
Affinity DataIC50:  81nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 in presence of E1 protein and PDC core E2/E3BP incubated for 10 mins by titration as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232911(CHEMBL4080613)
Affinity DataIC50:  91nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  110nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  130nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  140nMAssay Description:Inhibition of RAF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232915(CHEMBL4066580)
Affinity DataIC50:  154nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232916(CHEMBL4087901)
Affinity DataIC50:  156nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232905(CHEMBL4091824)
Affinity DataIC50:  195nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232917(CHEMBL4104250)
Affinity DataIC50:  221nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188941(CHEMBL380165 | N-((R)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  240nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188944(CHEMBL211578 | N-((S)-3-(2,4-dichlorophenyl)-1-hyd...)
Affinity DataIC50:  280nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM50232913(CHEMBL4103350)
Affinity DataIC50:  284nMAssay Description:Inhibition of recombinant human PDK4 in presence of E1 protein incubated for 10 mins by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232927(CHEMBL4102687)
Affinity DataIC50:  357nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  400nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232921(CHEMBL4080620)
Affinity DataIC50:  416nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM50232913(CHEMBL4103350)
Affinity DataIC50:  416nMAssay Description:Inhibition of recombinant human PDK4 in presence of E1 protein and PDC core E2/E3BP incubated for 10 mins by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232910(CHEMBL4097134)
Affinity DataIC50:  432nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM227594(PS10)
Affinity DataIC50:  456nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science

Curated by ChEMBL
LigandPNGBDBM50232925(CHEMBL4095603)
Affinity DataIC50:  565nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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