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Found 147 with Last Name = 'clarke' and Initial = 'f'
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042828(4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-car...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016895(5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-...)
Affinity DataIC50:  1.80nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptamine 1A receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataIC50:  2nMAssay Description:Concentration of the compound necessary to achieve half maximal inhibition of [3H]-clonidine binding to Alpha-2 adrenergic receptor at 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016900((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Affinity DataIC50:  2nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor at 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042835(1-(9-Mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50008790(5-[Pyridin-4-yl-(3-trifluoromethyl-phenyl)-methyle...)
Affinity DataIC50:  3nMAssay Description:Compound was evaluated in vitro for the inhibition of Thromboxane synthase using [14C]-arachidonic acid as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025953(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid | CGS-1...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003795(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataIC50:  3nMAssay Description:Concentration of the compound necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016883(1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-...)
Affinity DataIC50:  4nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptamine 1A receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM29644((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  4nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibition against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM82427(CAS_5985-38-6 | LEVORPHANOL-tartarate)
Affinity DataIC50:  4.5nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM82427(CAS_5985-38-6 | LEVORPHANOL-tartarate)
Affinity DataIC50:  4.5nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50008798(7-(3-Pyridin-3-yl-bicyclo[2.2.1]hept-2-yl)-heptano...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of thromboxane synthase using [14C]-arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016882(1-Butyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-p...)
Affinity DataIC50:  8nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016888(1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-...)
Affinity DataIC50:  9nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016890(5-Methoxy-1-propyl-2,3,4,4a,10,10a-hexahydro-1H-9-...)
Affinity DataIC50:  9nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptamine 1A receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  10nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50228062(CHEMBL165290)
Affinity DataIC50:  11nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042832(3-Hydroxy-2-[(9-mercaptomethyl-10-oxo-azecane-2-ca...)
Affinity DataIC50:  11nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283042((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283049((Z)-7-[(1R,2R,3S,5S)-5-(Biphenyl-4-ylmethoxy)-3-hy...)
Affinity DataIC50:  12nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042831(6-Amino-2-[(9-mercaptomethyl-10-oxo-azecane-2-carb...)
Affinity DataIC50:  14nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016885(1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-...)
Affinity DataIC50:  16nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283047((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)
Affinity DataIC50:  18nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50497043(CHEMBL3249802)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016899(8-Methoxy-1,5-dimethyl-2,3,4,4a,10,10a-hexahydro-1...)
Affinity DataIC50:  19nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptamine 1A receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50497043(CHEMBL3249802)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50228061(CHEMBL163167)
Affinity DataIC50:  20nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283050((Z)-7-[(2S,3R,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  22nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  22nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283048((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)
Affinity DataIC50:  24nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50016886(1,5-Dimethyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-...)
Affinity DataIC50:  26nMAssay Description:Concentration necessary to achieve half maximal inhibition of [3H](+)-23amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene binding to dopamine recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  27nMAssay Description:In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM7962(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)
Affinity DataIC50:  28nMAssay Description:Compound was evaluated in vitro for the inhibition of Thromboxane synthase using [14C]-arachidonic acid as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  28nMAssay Description:In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
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