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Found 580 with Last Name = 'collini' and Initial = 'm'
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50067536(5-Hydroxy-2,4-dimethyl-8-[2'-(1H-tetrazol-5-yl)-bi...)
Affinity DataIC50:  0.170nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152609(7-Bromo-2-(3-fluoro-4-hydroxy-phenyl)-benzofuran-5...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50471877(CHEMBL135574)
Affinity DataIC50:  0.410nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152616(4-Bromo-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.720nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152628(2-(3-Fluoro-4-hydroxy-phenyl)-5-hydroxy-benzofuran...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154088(7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol | 7-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  1.20nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470071(CHEMBL150507)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154078(7-Bromo-2-(4-hydroxy-2-methyl-phenyl)-benzooxazol-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470073(CHEMBL153188)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154059(7-Bromo-2-(2-fluoro-4-hydroxy-phenyl)-benzooxazol-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154137(3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154134(2-(4-Hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol |...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154048(3-(5-Hydroxy-naphthalen-1-yl)-benzo[d]isoxazol-6-o...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  1.5nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50152629(7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol | CHE...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity for human Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152626(7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol | CH...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity towards human estrogen receptor beta (ERbeta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154088(7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol | 7-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM20731(4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470063(CHEMBL152957)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20001(2-{4-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-...)
Affinity DataIC50:  1.90nM EC50:  33nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(RAT)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to rat ER alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154140(2-(2-Fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152629(7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol | CHE...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305501(CHEMBL590098 | ethyl 4-(3-(3-(methylsulfonyl)pheno...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227161(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227146(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227163(2-(4-((3-(3-benzoyl-8-(trifluoromethyl)quinolin-5-...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154088(7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol | 7-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152617(CHEMBL360385 | [4-Bromo-5-hydroxy-2-(4-hydroxy-phe...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154084(7-Bromo-2-(3-fluoro-4-hydroxy-phenyl)-benzooxazol-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM20734(4-chloro-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227157(2-(4-((3-(3-benzoyl-8-(trifluoromethyl)quinolin-5-...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at human LXRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  2.10nM EC50:  71nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154132(2-(2,6-Difluoro-4-hydroxy-phenyl)-7-vinyl-benzooxa...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152624(5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBO...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity for human Estrogen receptor betaMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470065(CHEMBL348472)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305499(4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluo...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154057(2-(4-Hydroxy-phenyl)-benzooxazol-5-ol | 2-(4-hydro...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to mouse ER alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50471878(CHEMBL337067)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470068(CHEMBL152958)
Affinity DataIC50:  2.30nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154064(2-(2-Fluoro-4-hydroxy-phenyl)-5-hydroxy-benzooxazo...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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