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Found 677 with Last Name = 'cumin' and Initial = 'f'
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17945((2S,4S,5S)-5-amino-N-butyl-4-hydroxy-9-[(2S)-2-[(m...)
Affinity DataIC50:  0.100nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98678(US8497286, 154)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98684(US8497286, 160)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98679(US8497286, 155)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18313((2R,4S,5S,7S)-5-amino-N-(2-acetamidoethyl)-4-hydro...)
Affinity DataIC50:  0.300nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054632(CHEMBL3318940)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM153128(US8993631, 36)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054540(CHEMBL3318939)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130359(US8822534, Example 5-39 | US8993631, 5-8)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18342((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18337((2S,4S,5S,7S)-5-amino-N-[2,2-dimethyl-2-(methylcar...)
Affinity DataIC50:  0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98679(US8497286, 155)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054633(CHEMBL3318941)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054637(CHEMBL3318938)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054636(CHEMBL3318937)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18288((2R,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  0.400nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17944(Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...)
Affinity DataIC50:  0.5nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18340((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98678(US8497286, 154)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98684(US8497286, 160)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18278((2R,4S,5S,7S)-5-amino-7-{[3-(benzyloxy)-4-methoxyp...)
Affinity DataIC50:  0.600nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.600nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98686(US8497286, 162)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18344((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18323((2S,4S,5S,7S)-5-amino-N-(3-carbamoylpropyl)-4-hydr...)
Affinity DataIC50:  0.700nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98685(US8497286, 161)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054634(CHEMBL3318942)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18289((2R,4S,5S,7S)-5-amino-4-hydroxy-N-(4-hydroxybutyl)...)
Affinity DataIC50:  0.800nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17943(Renin nonpeptide inhibitor, 3 | methyl (3S)-1-[(5S...)
Affinity DataIC50:  0.800nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18338((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.800nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18326((2S,4S,5S,7S)-5-amino-N-[(1S)-1-carbamoylpropyl]-4...)
Affinity DataIC50:  0.800nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509659(CHEMBL4443138)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18336((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18334((2S,4S,5S,7S)-5-amino-N-[(2R)-2-carbamoyl-2-methyl...)
Affinity DataIC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17948((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-({[2-(3-...)
Affinity DataIC50:  0.900nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM98673(US8497286, 149)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18306((2R,4S,5S,7S)-5-amino-N-(3-cyanopropyl)-4-hydroxy-...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50298192(CHEMBL561407 | N-((2S,3S,5R)-2-amino-6-(butylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50298193(CHEMBL557064 | N-((2S,3S,5R)-2-amino-6-(butylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50298200(CHEMBL550005 | N-((2S,3S,5S)-2-amino-5-(butylcarba...)
Affinity DataIC50:  1nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18304(8-phenyl-octanecarboxamide peptidomimetic, 61 | me...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18308((2R,4S,5S,7S)-5-amino-N-(3-carbamoylpropyl)-4-hydr...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50054636(CHEMBL3318937)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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