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Found 342 with Last Name = 'de winter' and Initial = 'h'
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM16152(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  10nMAssay Description:Inhibition of human uPA using S-2444 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  17nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  20nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50147422(3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic ...)
Affinity DataKi:  37nMAssay Description:Inhibition of human uPA using S-2444 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataKi:  410nMAssay Description:Inhibition of uPA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50228403((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136661((R)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136662((S)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121279(2-Amino-1-[2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydr...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136644((S)-2-Amino-1-[(S)-5-chloro-2-(5-propyl-1H-imidazo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121284(2-Amino-1-[2-(5-methyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136648((S)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121282((S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carb...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136667(2-Amino-1-[(S)-5-chloro-2-(5-propyl-1H-imidazol-2-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136645((S)-2-Amino-1-[(S)-5-methoxy-2-(5-propyl-1H-imidaz...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136654((S)-2-Amino-3-methyl-1-[(S)-2-(5-propyl-1H-imidazo...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121280(2-Amino-1-[2-(5-methyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121285((S)-2-Amino-1-[(S)-2-(5-ethyl-1H-imidazol-2-yl)-2,...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121283(2-Amino-1-[2-(1H-imidazol-2-yl)-2,3-dihydro-indol-...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136663(2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2,3-d...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136636(2-Amino-1-[(S)-5-fluoro-2-(5-propyl-1H-imidazol-2-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136666(2-Amino-1-[(S)-2-(5-butyl-1H-imidazol-2-yl)-2,3-di...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  51nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136656(2-Amino-1-[(S)-2-(4-methyl-5-propyl-1H-imidazol-2-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136660(2-Amino-1-[(S)-5-methoxy-2-(5-propyl-1H-imidazol-2...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277239(CHEMBL4175831)
Affinity DataIC50:  79nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  86nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50499900(CHEMBL3740183)
Affinity DataIC50:  97nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50225437((2S,3R)-2-amino-1-(isoindolin-2-yl)-3-methylpentan...)
Affinity DataIC50:  120nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136651(({2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50:  135nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  140nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263058(CHEMBL4090723)
Affinity DataIC50:  167nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50499914(CHEMBL3740973)
Affinity DataIC50:  174nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50:  178nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50499920(CHEMBL3741622)
Affinity DataIC50:  184nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136652(2-Amino-1-[(S)-2-(5-ethyl-1H-imidazol-2-yl)-2,3-di...)
Affinity DataIC50:  194nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136650(2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2-y...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  208nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263056(CHEMBL4064515)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136655(2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2-y...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263056(CHEMBL4064515)
Affinity DataIC50:  229nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50243649((2S,4S)-1-((2S,3R)-2-amino-3-methylpentanoyl)-4-az...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50499913(CHEMBL3741173)
Affinity DataIC50:  254nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Bos taurus)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50225437((2S,3R)-2-amino-1-(isoindolin-2-yl)-3-methylpentan...)
Affinity DataIC50:  290nMAssay Description:Inhibition of bovine DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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