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Target
Aurora kinase B
Ligand
BDBM50004205
Substrate
n/a
Meas. Tech.
ChEBML_1697674
IC50
68±n/a nM
Citation
 Hofmans, S; Devisscher, L; Martens, S; Van Rompaey, D; Goossens, K; Divert, T; Nerinckx, W; Takahashi, N; De Winter, H; Van Der Veken, P; Goossens, V; Vandenabeele, P; Augustyns, K Tozasertib Analogues as Inhibitors of Necroptotic Cell Death. J Med Chem 61:1895-1920 (2018) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50004205
Synonyms:
MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 | VX-68 | VX-680
Type:
Small organic molecule
Emp. Form.:
C23H28N8OS
Mol. Mass.:
464.586
SMILES:
CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Structure:
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