Affinity DataKi: 15.3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 67nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 176nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 830nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Displacement of [3H]DPCPX from A1 adenosine receptor in rat membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of GLS1 in human A549 cells assessed as reduction in conversion of glutamine to glutamate measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human spleen cathepsin D using 5-FAM/QXL as peptide substrate after 1 hr by FRET assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair