BDBM50085658 (2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol::(2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol::2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol::2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol(CCPA)::2-Cl-CPA::2-chloro-N6-cyclopentyladenosine::5-(2-Chloro-6-cyclopentylamino-purin-9-yl)-tetrahydro-furan-2,3,4-triol::CCPA::CHEMBL284969::N6-Cyclopentyl-2-chloroAdo

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12

InChI Key InChIKey=XSMYYYQVWPZWIZ-IDTAVKCVSA-N

Data  68 KI  3 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50085658   

TargetAdenosine receptor A1(Mouse)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Guinea pig)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in pig cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in bovine cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.350nMAssay Description:Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.600nMAssay Description:Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.830nM ΔG°:  -11.5kcal/molepH: 7.4 T: 4°CAssay Description:Radioligand binding assay using adenosine receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Guinea pig)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-CCPA from human A1 receptor stably expressed in CHO cell membranes by radioligand competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.30nMAssay Description:Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]CHA from Adenosine A1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1.5nMAssay Description:Tested for inhibition of adenosine A1 receptor binding to rat brainMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  6.40nMAssay Description:In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  7.43nMAssay Description:Binding affinity for adenosine A1 receptor was assayed by displacement of [3H]DPCPX from rat cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  9.47nMAssay Description:Affinity towards adenosine A1 receptor from rat cortical membranes using [3H]DPCPXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15.1nMAssay Description:Binding affinity to human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15.3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Mouse)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from mouse A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Human)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  17nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-HEMADO from human A3 receptor stably expressed in CHO cell membranes by radioligand competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  34nMAssay Description:Binding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor in the presence of GTPgammaS using [3H]8-ethyl-4-m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against Beta-glucosidase from AlmondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  38nMAssay Description:Binding affinity to human adenosine A3 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  38nMAssay Description:Bnding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-te...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  38nMAssay Description:Affinity for human Adenosine A3 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2b(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  42nMAssay Description:Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-NECA from human adenosine A3 receptor in stably transfected HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  100nMAssay Description:Binding affinity towards Adenosine A3 receptor (W243 mutant receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  114nMAssay Description:Binding affinity towards human Adenosine A3 receptor wild typeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  204nMAssay Description:Affinity towards Adenosine A3 receptor expressed in HEK 293 cells using [125I]AB-MECA radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  237nMAssay Description:Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  237nMAssay Description:Binding affinity to rat adenosine A3 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  237nMAssay Description:Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  281nMAssay Description:Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Human)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  580nMAssay Description:Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  605nMAssay Description:Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Human)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  639nMAssay Description:Tested for binding affinity towards human adenosine A2A receptor using [3H]ZM-241385 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  640nMAssay Description:Binding affinity for adenosine A2A receptor was determined by displacement of [3H]-DPCPX from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  650nMAssay Description:Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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