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Found 150 with Last Name = 'doyle' and Initial = 'jj'
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003168(2-Benzyl-N-(6-cyclohexylmethyl-7-hydroxy-10-morpho...)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003195(CHEMBL126115 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.230nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003191(CHEMBL338008 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.410nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003174(CHEMBL339289 | {2-[1-(6-Cyclohexylmethyl-7-hydroxy...)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003194(CHEMBL124616 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003176(2-[1-(6-Cyclohexylmethyl-7-hydroxy-10-morpholin-4-...)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005321(5-[2-(2-Acetylamino-3-phenyl-propionylamino)-hexan...)
Affinity DataIC50:  0.840nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003165(1N-[1-[12-cyclohexylmethyl-11-hydroxy-8-(1,4-oxazi...)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003181((diastereomer-1) (1-{6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003181((diastereomer-1) (1-{6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011704(CHEMBL170504 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003192(2-(1-Aza-bicyclo[2.2.2]oct-3-ylamino)-N-(6-cyclohe...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011704(CHEMBL170504 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011708(CHEMBL171319 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  1.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  1.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011713(CHEMBL430933 | {1-[1-(1-Cyclohexylmethyl-2,3-dihyd...)
Affinity DataIC50:  1.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50230157(CHEMBL3144232)
Affinity DataIC50:  1.70nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011706(CHEMBL353944 | {1-[1-[2-(1-Butyl-5,5-dimethyl-2-ox...)
Affinity DataIC50:  1.90nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005318(CHEMBL166771 | {1-[1-(4-Butylcarbamoyl-1-cyclohexy...)
Affinity DataIC50:  2.10nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011706(CHEMBL353944 | {1-[1-[2-(1-Butyl-5,5-dimethyl-2-ox...)
Affinity DataIC50:  2.40nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  2.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011710(CHEMBL355458 | {1-[1-[1-Cyclohexylmethyl-2-(5-ethy...)
Affinity DataIC50:  3.30nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003190((diastereomer-1)[1-(6-Cyclohexylmethyl-7-hydroxy-4...)
Affinity DataIC50:  3.40nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003177((diastereomer-1) [1-(6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003177((diastereomer-1) [1-(6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003188((diastereomer-1) [1-(6-Cyclohexylmethyl-10-dimethy...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003188((diastereomer-1) [1-(6-Cyclohexylmethyl-10-dimethy...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011710(CHEMBL355458 | {1-[1-[1-Cyclohexylmethyl-2-(5-ethy...)
Affinity DataIC50:  5.30nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011703(CHEMBL355128 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  5.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003171((diastereomer-1) [1-(6-Cyclohexylmethyl-10-diethyl...)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003171((diastereomer-1) [1-(6-Cyclohexylmethyl-10-diethyl...)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011693(CHEMBL352839 | {1-[1-{1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  7.70nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011698(CHEMBL354505 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  8nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011698(CHEMBL354505 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  8.5nMpH: 7.4Assay Description:Inhibitory concentration against GastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011695(CHEMBL170287 | {1-[1-[1-Cyclohexylmethyl-2-(5-ethy...)
Affinity DataIC50:  8.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011703(CHEMBL355128 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  9.30nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011707(CHEMBL405692 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011696(CHEMBL170772 | {1-[1-[1-Cyclohexylmethyl-2-(1-cycl...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003175(1H-Indole-2-carboxylic acid (6-cyclohexylmethyl-7-...)
Affinity DataIC50:  11nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011695(CHEMBL170287 | {1-[1-[1-Cyclohexylmethyl-2-(5-ethy...)
Affinity DataIC50:  11nMpH: 7.4Assay Description:Inhibitory concentration against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011707(CHEMBL405692 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  14nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011712(CHEMBL171185 | {1-[1-{2-[1-(3-Benzylamino-propyl)-...)
Affinity DataIC50:  14nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003183((diastereomer-1)[1-(7-Cyclohexylmethyl-6-hydroxy-3...)
Affinity DataIC50:  17nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003183((diastereomer-1)[1-(7-Cyclohexylmethyl-6-hydroxy-3...)
Affinity DataIC50:  17nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005312(5-[2-(3-Acetylamino-2-oxo-4-phenyl-piperidin-1-yl)...)
Affinity DataIC50:  21nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003173((diastereomer-1)[1-(10-Butyl-6-cyclohexylmethyl-7-...)
Affinity DataIC50:  22nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003173((diastereomer-1)[1-(10-Butyl-6-cyclohexylmethyl-7-...)
Affinity DataIC50:  22nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011714(CHEMBL435274 | {1-[1-{2-[1-(2-Benzyloxy-ethyl)-2-o...)
Affinity DataIC50:  24nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011699(CHEMBL171236 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)
Affinity DataIC50:  40nMpH: 7.4Assay Description:Inhibitory concentration against PepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011697(CHEMBL355726 | {1-[1-(1-Cyclohexylmethyl-3-dimethy...)
Affinity DataIC50:  45nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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