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Found 251 with Last Name = 'duffy' and Initial = 'kj'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079596(((S)-1-{N'-[2-((S)-1-Benzyloxycarbonylamino-3-meth...)
Affinity DataKi:  10nMAssay Description:Compound was tested for its inhibitory activity against human osteoclast cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079595(((R)-1-{[2-((S)-1-Benzyloxycarbonylamino-3-methyl-...)
Affinity DataKi:  33nMAssay Description:Compound was tested for its inhibitory activity against human osteoclast cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079597(((R)-1-{[2-((S)-1-Benzyloxycarbonylamino-3-methyl-...)
Affinity DataKi:  330nMAssay Description:Compound was tested for its inhibitory activity against human osteoclast cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV 1b NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220195(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV 2a NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181650(1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydro-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220159(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181560(3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]th...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181569(CHEMBL425221 | [3-(1,1-dioxo-1,4-dihydrobenzo[1,2,...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181589(1-(3,3-dimethylbutyl)-3-(1,1-dioxo-1,4-dihydrobenz...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181588(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181584(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220201(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181583(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220155(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220176(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM30406(CHEMBL176058 | benzo[1,2,4]thiadiazine-1,1-dioxide...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181634(6-Amino-1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-di...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181570(5-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181567(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181646(1-(3-bromobenzyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220162(CHEMBL243883 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181666(3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181579(6-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181615(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181623(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181601(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181580(1-(3,3-dimethylbutyl)-3-(1,1-dioxo-1,4-dihydrobenz...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against HCV 1a NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181624(1-cyclobutylmethyl-3-(1,1-dioxo-1,2-dihydrobenzo[1...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181596(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220188(CHEMBL244126 | N-(4'-t-butyl-4-biphenylyl)urea)
Affinity DataIC50:  54nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220192(CHEMBL397249 | N-(4'-isopropyl-4-biphenylyl)urea)
Affinity DataIC50:  57nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220177(CHEMBL389588 | N-{4'-[(trifluoromethyl)sulfonyl]-4...)
Affinity DataIC50:  58nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181598(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181593(6-amino-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadi...)
Affinity DataIC50:  62nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220172(4'-(trifluoromethyl)-4-biphenylyl sulfamate | CHEM...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181631(3-(1,1-Dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220209(CHEMBL242780 | N-[3-(methoxy)-4'-(trifluoromethyl)...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220181(CHEMBL397673 | N-[4-(2,2,3,3-tetrafluoro-2,3-dihyd...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220170(CHEMBL243649 | N-[3-Chloro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181660(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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