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Target
Cathepsin K
Ligand
BDBM50079595
Substrate
n/a
Meas. Tech.
ChEBML_48317
Ki
33±n/a nM
Citation
 Duffy, KJ; Ridgers, LH; DesJarlais, RL; Tomaszek, TA; Bossard, MJ; Thompson, SK; Keenan, RM; Veber, DF Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K. Bioorg Med Chem Lett 9:1907-10 (1999) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50079595
Synonyms:
((R)-1-{[2-((S)-1-Benzyloxycarbonylamino-3-methyl-butyl)-thiazole-4-carbonyl]-amino}-3-isobutyl-2-oxo-pyrrolidin-3-yl)-carbamic acid benzyl ester | CHEMBL294615
Type:
Small organic molecule
Emp. Form.:
C33H41N5O6S
Mol. Mass.:
635.774
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)c1nc(cs1)C(=O)NN1CC[C@@](CC(C)C)(NC(=O)OCc2ccccc2)C1=O
Structure:
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