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Found 283 with Last Name = 'forli' and Initial = 's'
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187566(4-iodo-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzam...)
Affinity DataKi:  400nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataKi:  420nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataKi:  420nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187573(3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-a...)
Affinity DataKi:  500nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187569(4-(4-iodobenzylidene)-1-(4-iodophenyl)pyrazolidine...)
Affinity DataKi:  500nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187573(3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-a...)
Affinity DataKi:  500nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187579(4-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)-1-(...)
Affinity DataKi:  500nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187575(4-benzylidene-1-(4-iodophenyl)pyrazolidine-3,5-dio...)
Affinity DataKi:  600nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187569(4-(4-iodobenzylidene)-1-(4-iodophenyl)pyrazolidine...)
Affinity DataKi:  800nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187570(4-(2-(benzyloxy)benzylidene)-1-phenylpyrazolidine-...)
Affinity DataKi:  900nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187577(4-(4-(diethylamino)-2-hydroxybenzylidene)-1-(4-iod...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187574(4-((5-(3-chloro-4-methylphenyl)furan-2-yl)methylen...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187572(4-(3-(benzyloxy)benzylidene)-1-(3,4-dichlorophenyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187568(2,4-dichloro-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187565(2-iodo-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzam...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187576(BAS-4844343 | CHEMBL207672 | N-(5-((1H-indol-3-yl)...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187571(2-methoxy-4-(methylthio)-N-(5-phenethyl-1,3,4-thia...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187565(2-iodo-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzam...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187579(4-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)-1-(...)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187578(BAS-0338868 | CHEMBL378903 | N-(5-phenethyl-1,3,4-...)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187571(2-methoxy-4-(methylthio)-N-(5-phenethyl-1,3,4-thia...)
Affinity DataKi:  4.10E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187575(4-benzylidene-1-(4-iodophenyl)pyrazolidine-3,5-dio...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187574(4-((5-(3-chloro-4-methylphenyl)furan-2-yl)methylen...)
Affinity DataKi:  5.00E+3nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187572(4-(3-(benzyloxy)benzylidene)-1-(3,4-dichlorophenyl...)
Affinity DataKi:  5.40E+3nMAssay Description:Binding affinity to human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187580(4-(4-morpholinobenzylidene)-1-(4-iodophenyl)pyrazo...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187567(1-(5-benzyl-1,3,4-thiadiazol-2-yl)-3-phenylurea | ...)
Affinity DataKi:  5.80E+4nMAssay Description:Binding affinity to human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308732(CHEMBL605820 | Isopropyl-2-methyl-5-[4-(methylsulf...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(CHEMBL237592 | ethyl-2-methyl-5-[4-(methylsulfonyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50224129(CHEMBL237626 | ethyl-2-methyl-5-[4-(methylsulfonyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308736(CHEMBL602237 | n-Butyl-2-Methyl-5-[4-(methylsulfon...)
Affinity DataIC50:  14nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50224128(CHEMBL238027 | ethyl-2-methyl-5-[4-(methylsulfonyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308738(CHEMBL589813 | Isopropyl-2-methyl-5-[4-(methylsulf...)
Affinity DataIC50:  21nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308740(CHEMBL600167 | Isopropyl-2-methyl-5-[4-(methylsulf...)
Affinity DataIC50:  22nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308737(CHEMBL600844 | n-Butyl-2-methyl-5-[4-(methylsulfon...)
Affinity DataIC50:  24nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50224122(CHEMBL398382 | ethyl-2-methyl-5-[4-(methylsulfonyl...)
Affinity DataIC50:  26nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308735(2-Methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(fluoro...)
Affinity DataIC50:  28nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308739(CHEMBL589087 | n-Butyl-2-methyl-5-[4-(methylsulfon...)
Affinity DataIC50:  30nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308741(CHEMBL589166 | n-Butyl-2-methyl-5-[4-(methylsulfon...)
Affinity DataIC50:  38nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50166278(CHEMBL191941 | [5-(4-Methanesulfonyl-phenyl)-2-met...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50308734(CHEMBL589812 | Isopropyl-2-methyl-5-[4-(methylsulf...)
Affinity DataIC50:  43nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  60nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  60nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50253541((-)-(R)-Ethyl-[2-hydroxy-2-[1-(3-fluoro)phenyl-2-m...)
Affinity DataIC50:  75nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50253543((+)-(S)-Ethyl-[2-hydroxy-2-[1-(4-methoxy)phenyl-2-...)
Affinity DataIC50:  79nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  79nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50253627((-)-(R)-Ethyl-[2-ethoxy-2-[1-(4-methoxy)phenyl-2-m...)
Affinity DataIC50:  90nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50253569((+/-)-Ethyl-[2-ethoxy-2-[1-(3-fluoro)phenyl-2-meth...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50253567((+)-(S)-Ethyl-[2-ethoxy-2-[-2-methyl-5-(4-methylsu...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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