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TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123070(US8742115, 9)
Affinity DataKi:  0.900nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123096(US10213421, Example 10 | US11612596, Example 10. |...)
Affinity DataKi:  1.70nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123082(US10213421, Example 8 | US11612596, Example 8. | U...)
Affinity DataKi:  2.30nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123092(US8742115, 32)
Affinity DataKi:  2.30nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123072(US10213421, Example 2 | US11612596, Example 2. | U...)
Affinity DataKi:  3.20nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123076(US10213421, Example 3 | US11612596, Example 3. | U...)
Affinity DataKi:  3.5nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123080(US10213421, Example 6 | US11612596, Example 6. | U...)
Affinity DataKi:  4nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123089(US8742115, 29)
Affinity DataKi:  4.10nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123083(US10213421, Example 9 | US11612596, Example 9. | U...)
Affinity DataKi:  4.20nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123078(US10213421, Example 4 | US11612596, Example 4. | U...)
Affinity DataKi:  4.30nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123079(US10213421, Example 5 | US11612596, Example 5. | U...)
Affinity DataKi:  4.60nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123073(US8742115, 12)
Affinity DataKi:  4.70nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123081(US10213421, Example 7 | US11612596, Example 7. | U...)
Affinity DataKi:  5.20nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123084(US8742115, 24)
Affinity DataKi:  5.80nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123071(US8742115, 10)
Affinity DataKi:  6nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123077(US8742115, 16)
Affinity DataKi:  6.80nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123094(US8742115, 34)
Affinity DataKi:  7.90nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123093(US8742115, 33)
Affinity DataKi:  7.90nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123085(US8742115, 25)
Affinity DataKi:  8.30nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123069(US8742115, 8)
Affinity DataKi:  8.5nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123068(US10213421, Example 1 | US11612596, Example 1. | U...)
Affinity DataKi:  10.4nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMax-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388975(CHEMBL2063869)
Affinity DataKi:  14nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMax-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388974(CHEMBL2063868)
Affinity DataKi:  16nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388975(CHEMBL2063869)
Affinity DataKi:  17nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from cIAP1 BIR3 domain after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123088(US8742115, 28)
Affinity DataKi:  17.8nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123074(US8742115, 13)
Affinity DataKi:  19.1nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123062(US8742115, 1)
Affinity DataKi:  23.4nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388975(CHEMBL2063869)
Affinity DataKi:  28nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMax-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388969(CHEMBL2063862)
Affinity DataKi:  30nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2 [266-354](Homo sapiens (Human))
Genentech

LigandPNGBDBM17344((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMax-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388970(CHEMBL2063863)
Affinity DataKi:  30nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2 [266-354](Homo sapiens (Human))
Genentech

LigandPNGBDBM27919(Azabicyclooctane scaffold, 14b | N-[(3aR,6S,6aS)-1...)
Affinity DataKi:  33nMAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388974(CHEMBL2063868)
Affinity DataKi:  35nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27920(Azabicyclooctane scaffold, 14c | N-[(3aR,6S,6aS)-1...)
Affinity DataKi:  38nM ΔG°:  -41.9kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17344((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
LigandPNGBDBM27942((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  43nM ΔG°:  -41.6kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388975(CHEMBL2063869)
Affinity DataKi:  43nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from cIAP2 BIR3 domain after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27919(Azabicyclooctane scaffold, 14b | N-[(3aR,6S,6aS)-1...)
Affinity DataKi:  46nM ΔG°:  -41.5kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123064(US8742115, 3)
Affinity DataKi:  46.5nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Genentech

LigandPNGBDBM17344((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2 [266-354](Homo sapiens (Human))
Genentech

LigandPNGBDBM17345((3R,6S,9aR)-2,2-dimethyl-N-(3-methyl-1-phenyl-1H-p...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17345((3R,6S,9aR)-2,2-dimethyl-N-(3-methyl-1-phenyl-1H-p...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123095(US8742115, 35)
Affinity DataKi:  61.3nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM27921(Azabicyclooctane scaffold, 14d | N-[(3aR,6S,6aS)-1...)
Affinity DataKi:  63nM ΔG°:  -40.7kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123065(US8742115, 4)
Affinity DataKi:  67.5nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123063(US8742115, 2)
Affinity DataKi:  69.6nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMax-like protein X(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50388968(CHEMBL2063866)
Affinity DataKi:  70nMAssay Description:Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3 [252-340](Homo sapiens (Human))
Genentech

LigandPNGBDBM17344((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123090(US8742115, 30)
Affinity DataKi:  70.3nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM123067(US8742115, 6)
Affinity DataKi:  72nMAssay Description:The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxi...More data for this Ligand-Target Pair
In DepthDetails US Patent
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